Reactome | KLC1 [cytosol]

KLC1 [cytosol]

Stable Identifier

R-HSA-983284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kinesin light chain 1, KLC1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07866 KLC1

Gene Names

KLC1, KLC, KNS2

Chain

chain:1-573

Reference Genes

BioGPS Gene:3831 KLC1

COSMIC (genes):KLC1 KLC1

CTD Gene:3831 KLC1

dbSNP Gene:3831 KLC1

ENSEMBL:ENSG00000126214 KLC1

HGNC:6387 KLC1

KEGG:hsa:3831 KLC1

Monarch:3831 KLC1

NCBI Gene:3831 KLC1

OMIM:600025 KLC1

UCSC:Q07866 KLC1

Reference Transcript

Participates

as a member of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)

Other forms of this molecule

KLC1(1-420)-ALK(1058-1620) fusion [cytosol]

KLC1(1-420)-p-7Y-ALK(1058-1620) fusion [cytosol]

Inferred To

klc3 [cytosol] (Danio rerio)

klc-2 [cytosol] (Caenorhabditis elegans)

klc1 [cytosol] (Xenopus tropicalis)

KLC1 [cytosol] (Bos taurus)

KLC1 [cytosol] (Canis familiaris)

KLC1 [cytosol] (Gallus gallus)

KLC1 [cytosol] (Sus scrofa)

Klc [cytosol] (Drosophila melanogaster)

Klc1 [cytosol] (Mus musculus)

Klc1 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000126214

ENSEMBL

ENST00000634686, ENSP00000450648, ENST00000334553, ENSP00000374394, ENST00000452929, ENSP00000450616, ENST00000554228, ENSP00000414982, ENSP00000334523, ENST00000246489, ENST00000557450, ENST00000553286, ENSP00000341154, ENSP00000488938, ENSP00000452487, ENSP00000246489, ENSG00000126214, ENST00000347839, ENSP00000334618, ENST00000389744, ENST00000348520

HPA

ENSG00000126214-KLC1

GeneCards

KLC1

PRO

Q07866

Pharos - Targets

Q07866

GlyGen

Q07866

PDB

5OJ8, 3NF1, 7AI4, 7AIE

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.826	6
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.802	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.601	4
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2