NPM binds PKR

Stable Identifier
R-HSA-9835328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NPM binds PKR
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Nucleophosmin (NPM1, B23) binds inactive protein kinase R (PKR, EIF2AK2), preventing its activation, thereby stimulating protein translation and suppressing apoptosis. NPM1 can shuttle between the nucleus and the cytosol. It is currently unknown whether it binds to PKR in the nucleus or the cytosol, but here we represent this reaction occuring in the cytosol (Pang et al, 2003).
Literature References
PubMed ID Title Journal Year
12882984 Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

Pang, Q, Faulkner, GR, Koretsky, T, Speckhart, A, David, L, Christianson, TA, Bagby, GC, Carlson, H, Keeble, W

J Biol Chem 2003
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Orthologous Events
NPM binds PKR (Bos taurus)
NPM binds PKR (Canis familiaris)
NPM binds PKR (Drosophila melanogaster)
NPM binds PKR (Gallus gallus)
NPM binds PKR (Mus musculus)
NPM binds PKR (Rattus norvegicus)
NPM binds PKR (Sus scrofa)
NPM binds PKR (Xenopus tropicalis)
Authored
Stephan, R  (2023-05-12)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-13)
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