Reactome | p-PKR dimer phosphorylates DHX9

p-PKR dimer phosphorylates DHX9

Stable Identifier

R-HSA-9836159

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ATP-dependent RNA helicase A (DHX9, RHA, DDX9) unwinds numerous nucleic acid substrates such as dsDNA and dsRNA, facilitating viral replication. Protein kinase R (PKR, EIF2AK2) phosphorylates DHX9, perturbing its association with dsRNA. Modification occurs in the first 263 amino acids of DHX9, where the dsRNA binding motifs are located. Blocking the interaction between PKR and DHX9 increases the infectivity of HIV-1 (Fujii et al, 2001; Sadler et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19229320	An antiviral response directed by PKR phosphorylation of the RNA helicase A Williams, BR, Hawkes, D, Latchoumanin, O, Mak, J, Sadler, AJ	PLoS Pathog	2009
11096080	A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1 Fujii, R, Taira, K, Nakajima, T, Ohshima, T, Baba, M, Fukamizu, A, Oishi, T, Aratani, S, Okamoto, M	J Biol Chem	2001