p-PKR dimer phosphorylates MAPT

Stable Identifier
R-HSA-9836404
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated PKR phosphorylates the 2N4F isoform of microtubule-associated protein tau (tau-F, tau-8, MAPT-8) at several serine and threonine residues. In neurons phosphorylated tau dissociates from microtubules, leaving them unstable, and accumulates outside the axon. Accumulation and self-assembly of tau are parts of so-called tau pathology in several neurodegenerative diseases (Reimer et al, 2021).
Literature References
PubMed ID Title Journal Year
32716602 PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation

Volbracht, C, Ă–verby, AK, Betzer, C, Kurhade, C, Kofoed, RH, Nilsson, E, Fog, K, Reimer, L, Jensen, PH

Brain Pathol 2021
Participants
Participates
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [cytosol]

Orthologous Events
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