Reactome | SPHK1 [nucleoplasm]

SPHK1 [nucleoplasm]

Stable Identifier

R-HSA-9836616

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Sphingosine kinase 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NYA1 SPHK1

Gene Names

SPHK1, SK1, SPHK, SPK

Chain

chain:1-384

Reference Genes

COSMIC (genes):SPHK1 SPHK1

dbSNP Gene:8877 SPHK1

ENSEMBL:ENSG00000176170 SPHK1

Participates

as an input of

p-PKR dimer phosphorylates SPHK1 (Homo sapiens)

Other forms of this molecule

p-S225-SPHK1 [nucleoplasm]

p-S225-SPHK1 [cytosol]

SPHK1 [cytosol]

Inferred To

Sk1 [nucleoplasm] (Drosophila melanogaster)

SPHK1 [nucleoplasm] (Bos taurus)

SPHK1 [nucleoplasm] (Caenorhabditis elegans)

SPHK1 [nucleoplasm] (Canis familiaris)

SPHK1 [nucleoplasm] (Dictyostelium discoideum)

SPHK1 [nucleoplasm] (Gallus gallus)

SPHK1 [nucleoplasm] (Mus musculus)

SPHK1 [nucleoplasm] (Rattus norvegicus)

SPHK1 [nucleoplasm] (Saccharomyces cerevisiae)

SPHK1 [nucleoplasm] (Schizosaccharomyces pombe)

SPHK1 [nucleoplasm] (Sus scrofa)

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q2M3C7 SPKAP			0.602	4
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.544	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.543	7
UniProt:Q96PQ7 KLHL5	1	KLHL5 [cytosol] (R-HSA-8863223)	0.482	2

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