p-PKR dimer phosphorylates SPHK1

Stable Identifier
R-HSA-9836617
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-PKR dimer phosphorylates SPHK1
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Activated PKR phosphorylates sphingosin kinase 1 (SPHK1) at S225 in the nucleus, priming it for nuclear export. This process is part of a feedback loop between PKR and SPHK1, activating pro-survival pathways in the cellular response to external stimuli (Qiao et al, 2020).
Literature References
PubMed ID Title Journal Year
32801355 Cell fate determined by the activation balance between PKR and SPHK1

Deng, Y, Jiang, T, Chen, X, Wen, X, Tang, S, Qiao, H, Mu, P, Hu, Z, Wen, J

Cell Death Differ 2021
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase activity of p-EIF2AK2 dimer [nucleoplasm]

Physical Entity
p-EIF2AK2 dimer [nucleoplasm] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Orthologous Events
p-PKR dimer phosphorylates SPHK1 (Bos taurus)
p-PKR dimer phosphorylates SPHK1 (Caenorhabditis elegans)
p-PKR dimer phosphorylates SPHK1 (Canis familiaris)
p-PKR dimer phosphorylates SPHK1 (Drosophila melanogaster)
p-PKR dimer phosphorylates SPHK1 (Gallus gallus)
p-PKR dimer phosphorylates SPHK1 (Mus musculus)
p-PKR dimer phosphorylates SPHK1 (Rattus norvegicus)
p-PKR dimer phosphorylates SPHK1 (Sus scrofa)
Authored
Stephan, R  (2023-05-31)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-31)
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