Reactome | The Immunoglobulin of the BCR binds antigen

The Immunoglobulin of the BCR binds antigen

Stable Identifier

R-HSA-983696

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

The Immunoglobulin of the B Cell Receptor Binds Antigen

ReviewStatus

5/5

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The Immunoglobulin of the BCR binds antigen

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Mature, unstimulated B cells express IgM and IgD immunoglobulins on their surfaces (Fu et al. 1974, Fu et al. 1975, reviewed in Kunkel 1975). The immunoglobulins form B cell receptor (BCR) complexes with disulfide-linked heterodimers of Ig-alpha (CD79A) and Ig-beta (CD79B), which have cytoplasmic tails containing immunoreceptor tyrosine-based activation motifs (ITAMs) (van Noesel et al. 1992, Saouaf et al. 1995, inferred from mouse Hombach et al. 1990, Wienands et al. 1990). Upon binding of antigen to the immunoglobulin a chain of phosphorylation events is triggered (Nel et al. 1984, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Harwood and Batista 2010).

Literature References

PubMed ID	Title	Journal	Year
7592958	Reconstitution of the B cell antigen receptor signaling components in COS cells Saouaf, SJ, Mahajan, S, Bolen, JB, Fargnoli, J, Kut, SA, Rowley, RB	J Biol Chem	1995
7927516	Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking Kawakami, T, Nakamura, T, Hata, D, Mayumi, M, Herren, B, Kawakami, Y	Immunol Lett	1994
20192804	Early events in B cell activation Batista, FD, Harwood, NE	Annu Rev Immunol	2010
6335036	Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin Nel, AE, Galbraith, RM, Goldschmidt-Clermont, PJ, Tung, HE, Landreth, GE	Biochem Biophys Res Commun	1984
7524079	Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement Saouaf, SJ, Bolen, JB, Tsukada, S, Fargnoli, J, Mahajan, S, Burkhardt, AL, Kut, SA, Rowley, RB, Witte, ON	Proc Natl Acad Sci U S A	1994
1081164	Surface markers of human lymphocytes Kunkel, HG	Johns Hopkins Med J	1975
2303036	Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM Radbruch, A, Reth, M, Riesterer, C, Hombach, J, Wienands, J	EMBO J	1990
803528	Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes Winchester, RJ, Fu, SM, Kunkel, HG	J Immunol	1975
1375264	Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers Van Noesel, CJ, Mason, DY, Bende, RJ, van Schijndel, GM, Borst, J, van Lier, RA, Brouns, GS	J Exp Med	1992
4589993	Occurrence of surface IgM, IgD, and free light chains of human lymphocytes Winchester, RJ, Fu, SM, Kunkel, HG	J Exp Med	1974
2304550	Molecular components of the B-cell antigen receptor complex of the IgM class Reth, M, Stappert, H, Hombach, J, Leclercq, L, Tsubata, T	Nature	1990