Reactome | GRSF1 [mitochondrial matrix]

GRSF1 [mitochondrial matrix]

Stable Identifier

R-HSA-9837006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

G-rich sequence factor 1, GRSF1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12849 GRSF1

Gene Names

GRSF1

Chain

transit peptide:1-117, chain:118-480

Reference Genes

BioGPS Gene:2926 GRSF1

COSMIC (genes):GRSF1 GRSF1

CTD Gene:2926 GRSF1

dbSNP Gene:2926 GRSF1

ENSEMBL:ENSG00000132463 GRSF1

HGNC:4610 GRSF1

KEGG:hsa:2926 GRSF1

Monarch:2926 GRSF1

NCBI Gene:2926 GRSF1

OMIM:604851 GRSF1

UCSC:Q12849 GRSF1

Reference Transcript

Other Identifiers

11732170_a_at

11732171_x_at

11745802_a_at

11747533_a_at

16976655

201501_PM_s_at

201501_s_at

201520_PM_s_at

201520_s_at

215030_PM_at

215030_at

2772620

2772621

2772622

2772623

2772624

2772625

2772626

2772627

2772631

2772632

2772633

2772634

2772635

2772636

2772637

2772640

2772643

2772644

2772645

2772646

2772648

2772649

2772650

2772651

2772652

2772653

2772654

2772655

2772656

2772657

2772679

2772680

2926

32595_at

8100834

A_23_P212937

GE58890

GE83795

GO:0000957

GO:0000962

GO:0002151

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0006397

GO:0006399

GO:0008033

GO:0009952

GO:0016071

GO:0016331

GO:0035770

GO:0042645

GO:0043226

GO:0043484

GO:1990904

HMNXSV003010357

Hs.287551.0.S1_3p_at

Hs.79295.0.A1_3p_a_at

ILMN_1806601

ILMN_1914378

PH_hs_0015866

PH_hs_0036518

TC04001272.hg

U07231_at

g4504160_3p_a_at

Participates

as an input of

GRSF1 binds RNA containing quadruplex guanosine (Homo sapiens)

as an output of

GRSF1 unwinds quadruplex G regions in RNA (Homo sapiens)

as a component of

GRSF1:MT-ND6 mRNA, antisense MT-CYB, MT-ND4, MT-ND5 with quadruplex G [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

GRSF1 [cytosol]

Inferred To

Grsf1 [mitochondrial matrix] (Mus musculus)

Grsf1 [mitochondrial matrix] (Rattus norvegicus)

grsf1 [mitochondrial matrix] (Xenopus tropicalis)

hrpf-1 [mitochondrial matrix] (Caenorhabditis elegans)

hrpf-2 [mitochondrial matrix] (Caenorhabditis elegans)

GRSF1 [mitochondrial matrix] (Bos taurus)

GRSF1 [mitochondrial matrix] (Canis familiaris)

GRSF1 [mitochondrial matrix] (Gallus gallus)

GRSF1 [mitochondrial matrix] (Sus scrofa)

glo [mitochondrial matrix] (Drosophila melanogaster)

Homologues of GRSF1 [mitochondrial matrix] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000502323, ENSP00000254799, ENST00000254799, ENSG00000132463, ENSP00000425430

OpenTargets

ENSG00000132463

GeneCards

GRSF1

HPA

ENSG00000132463-GRSF1

PRO

Q12849

Pharos - Targets

Q12849

GlyGen

Q12849

PDB

4QU7, 2LMI, 4QU6

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.558	4
UniProt:Q15349 RPS6KA2	7	p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) RPS6KA2 [cytosol] (R-HSA-444252) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [nucleoplasm] (R-HSA-199861)	0.527	2
UniProt:P38935 SMBP2			0.527	2
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.527	2

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