Reactome | SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP

SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP

Stable Identifier

R-HSA-9837333

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix

Synonyms

ADP(in) + CoA(out) => ADP(out) + CoA(in)

ReviewStatus

5/5

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SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP

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SLC25A42 associated with the inner mitochondrial membrane mediates the exchange of cytosolic CoA-SH for mitochondrial ADP. In vitro, SLC25A42 also shows a high transport affinity for dephospho-CoA (DP-CoA), and adenosine 3′,5′-diphosphate (PAP), not annotated here (Cavestro et al. 2023, Fiermonte et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19429682	A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria Fiermonte, G, Paradies, E, Todisco, S, Marobbio, CM, Palmieri, F	J Biol Chem	2009
36983025	Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments Cavestro, C, Diodato, D, Tiranti, V, Di Meo, I	Int J Mol Sci	2023