Reactome | DCAKD phosphorylates DP-CoA

DCAKD phosphorylates DP-CoA

Stable Identifier

R-HSA-9837337

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

Synonyms

3'-dephospho-CoA + ATP => ADP + CoA + H(+)

ReviewStatus

5/5

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Daugherty et al. (2002) identified a candidate monofunctional dephospho-CoA kinase, DCAKD (dephospho-CoA kinase domain-containing protein) on the basis of sequence homology. They suggest that DCAKD may increase the efficiency of dephospho-CoA to CoA conversion in vivo, based on the observation that although both phosphopantetheine adenylyltransferase and dephospho-CoA kinase activities are associated with the mitochondrial matrix, only dephospho-CoA kinase activity is present in the intermembrane space and in the outer membrane fraction.

Literature References

PubMed ID	Title	Journal	Year
11923312	Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics Osterman, A, Farrell, M, Daugherty, M, de Crecy-Lagard, V, Scholle, M, Polanuyer, B, Lykidis, A	J Biol Chem	2002