Reactome | p-S55,S56,S61,S160-TFAM [mitochondrial matrix]

p-S55,S56,S61,S160-TFAM [mitochondrial matrix]

Stable Identifier

R-HSA-9838277

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

fullName evidence="19"Transcription factor A, mitochondrial, TFAM_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O00411 POLRMT

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External Reference Information

External Reference

UniProt:Q00059 TFAM

Gene Names

TFAM, TCF6, TCF6L2

Chain

transit peptide:1-42, chain:43-246

Reference Genes

BioGPS Gene:7019 TFAM

COSMIC (genes):TFAM TFAM

CTD Gene:7019 TFAM

dbSNP Gene:7019 TFAM

ENSEMBL:ENSG00000108064 TFAM

ENSEMBL_homo_sapiens_GENE:ENSG00000108064.11 TFAM

HGNC:11741 TFAM

KEGG Gene (Homo sapiens):7019 TFAM

Monarch:7019 TFAM

NCBI Gene:7019 TFAM

OMIM:600438 TFAM

UCSC:Q00059 TFAM

Reference Transcript

Other Identifiers

11743810_s_at

11743811_a_at

11743812_x_at

16705074

203176_PM_s_at

203176_s_at

203177_PM_x_at

203177_x_at

208541_3p_x_at

208541_PM_x_at

208541_x_at

238443_3p_at

238443_PM_at

238443_at

238836_PM_at

238836_at

3247786

3247787

3247788

3247789

3247790

3247794

3247795

3247796

3247797

3247798

3247800

3247801

3247802

3247803

3247804

3247805

3247806

3247807

3247808

36191_at

4124596

51741_at

7019

73124_at

75940_at

7927669

A_14_P131101

A_23_P202258

A_24_P927537

A_33_P3389188

GE503155

GE58018

GO:0000976

GO:0001018

GO:0001223

GO:0001666

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005739

GO:0005759

GO:0005829

GO:0006351

GO:0006355

GO:0006390

GO:0006391

GO:0007005

GO:0007584

GO:0031072

GO:0032991

GO:0033108

GO:0034246

GO:0042645

GO:0043226

GO:0043565

GO:0045893

GO:0065003

GO:0140053

GO:0140110

HMNXSV003048540

Hs.198113.0.A1_3p_at

Hs.198113.0.A1_3p_x_at

Hs.222851.0.S1_3p_at

Hs.75133.0.A1_3p_a_at

ILMN_1715661

M62810_at

PH_hs_0028964

PH_hs_0040554

TC10000361.hg

TC10002078.hg

g4507400_3p_a_at

g6912699_3p_s_at

Participates

as a member of

Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)

as an output of

PRKACA phosphorylates TFAM in the mitochondrial matrix (Homo sapiens)

Other forms of this molecule

TFAM [mitochondrial matrix]

TFAM(1-246) [cytosol]

Inferred To

phospho-TFAM [mitochondrial matrix] (Bos taurus)

phospho-TFAM [mitochondrial matrix] (Canis familiaris)

phospho-TFAM [mitochondrial matrix] (Sus scrofa)

phospho-cmb1 [mitochondrial matrix] (Schizosaccharomyces pombe)

phospho-hmg-1.1 [mitochondrial matrix] (Caenorhabditis elegans)

phospho-nhp6 [mitochondrial matrix] (Dictyostelium discoideum)

phospho-nhp6 [mitochondrial matrix] (Schizosaccharomyces pombe)

phospho-HMO1 [mitochondrial matrix] (Saccharomyces cerevisiae)

phospho-ABF2 [mitochondrial matrix] (Saccharomyces cerevisiae)

phospho-NHP10 [mitochondrial matrix] (Saccharomyces cerevisiae)

phospho-HmgD [mitochondrial matrix] (Drosophila melanogaster)

phospho-IXR1 [mitochondrial matrix] (Saccharomyces cerevisiae)

phospho-NHP6A [mitochondrial matrix] (Saccharomyces cerevisiae)

phospho-Tfam [mitochondrial matrix] (Mus musculus)

phospho-Tfam [mitochondrial matrix] (Rattus norvegicus)

phospho-p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (Gallus gallus)

phospho-p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (Plasmodium falciparum)

phospho-p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (Schizosaccharomyces pombe)

phospho-tfam [mitochondrial matrix] (Danio rerio)

phospho-tfam [mitochondrial matrix] (Xenopus tropicalis)

Homologues of p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (Saccharomyces cerevisiae)

Homologues of p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-serine at 55

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 56

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 61

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 160

Coordinate

160

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003192.1, NP_001257711.1

OpenTargets

ENSG00000108064

HPA

ENSG00000108064-TFAM

GeneCards

Q00059

Ensembl

ENSP00000363002, ENST00000487519, ENSP00000420588, ENSG00000108064, ENST00000373895

PRO

Q00059

Pharos - Targets

Q00059

Orphanet

25193

PDB

6ERQ, 3TMM, 6HC3, 6HB4, 7LBX, 4NOD, 6ERP, 7LBW, 3FGH, 4NNU, 3TQ6

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.659	4
UniProt:O00411 POLRMT	1	POLRMT [mitochondrial matrix] (R-HSA-163267)	0.564	2
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.556	3
UniProt:O60635 TSN1			0.556	3
UniProt:Q4VAQ0 Q4VAQ0			0.556	3
UniProt:P02808 STAT			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q8WVM0 TFB1M	1	TFB1M [mitochondrial matrix] (R-HSA-1592207)	0.544	2
UniProt:Q14197 MRPL58	2	ICT1 [mitochondrial matrix] (R-HSA-5368175) ICT1 [mitochondrial inner membrane] (R-HSA-5624366)	0.527	2
UniProt:O15355 PPM1G			0.527	2
UniProt:O35658	2	C1qbp [plasma membrane] (R-MMU-158123) C1qbp [cytosol] (R-MMU-9645690)	0.462	2

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