Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species
Stable Identifier
R-HSA-9841244
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The presence of unfolded protein in the mitochondrial intermembrane space causes the cytosolic kinase AKT to be phosphorylated on serine-473 by an uncharacterized mechanism that requires the generation of reactive oxygen species (Papa and Germain 2011).
Literature References
PubMed ID
Title
Journal
Year
21486948
Estrogen receptor mediates a distinct mitochondrial unfolded protein response
Papa, L
,
Germain, D
J Cell Sci
2011
Participants
Input
AKT1 [cytosol]
(Homo sapiens)
ATP [cytosol]
Output
ADP [cytosol]
p-S473-AKT1 [cytosol]
(Homo sapiens)
Participates
as an event of
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
Orthologous Events
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Caenorhabditis elegans)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Danio rerio)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Dictyostelium discoideum)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Drosophila melanogaster)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Gallus gallus)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Mus musculus)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Rattus norvegicus)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Saccharomyces cerevisiae)
Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species (Schizosaccharomyces pombe)
Authored
May, B (2023-08-09)
Created
May, B (2023-08-11)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text