Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species

Stable Identifier
R-HSA-9841244
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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The presence of unfolded protein in the mitochondrial intermembrane space causes the cytosolic kinase AKT to be phosphorylated on serine-473 by an uncharacterized mechanism that requires the generation of reactive oxygen species (Papa and Germain 2011).
Literature References
PubMed ID Title Journal Year
21486948 Estrogen receptor mediates a distinct mitochondrial unfolded protein response

Papa, L, Germain, D

J Cell Sci 2011
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