FOXO3 translocates from the mitochondrial matrix to the nucleus

Stable Identifier
R-HSA-9841812
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix, nucleoplasm
ReviewStatus
3/5
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FOXO3 translocates from the mitochondrial matrix to the nucleus
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Deacetylation of FOXO3 promotes its nuclear localization (Tseng et al. 2013, Papa and Germain 2014) and its activation of the SOD2 (MnSOD) gene and the catalase (CAT gene (Papa and Germain 2014).
Literature References
PubMed ID Title Journal Year
24324009 SirT3 regulates the mitochondrial unfolded protein response

Papa, L, Germain, D

Mol Cell Biol 2014
23665396 SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

Tseng, AH, Shieh, SS, Wang, DL

Free Radic. Biol. Med. 2013
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Orthologous Events
FOXO3 translocates from the mitochondrial matrix to the nucleus (Bos taurus)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Caenorhabditis elegans)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Canis familiaris)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Danio rerio)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Drosophila melanogaster)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Gallus gallus)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Mus musculus)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Rattus norvegicus)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Sus scrofa)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Xenopus tropicalis)
Authored
May, B  (2023-08-11)
Created
May, B  (2023-08-15)
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