Reactome | MPHOSPH8 [nucleoplasm]

MPHOSPH8 [nucleoplasm]

Stable Identifier

R-HSA-9844052

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

M-phase phosphoprotein 8, MPP8_HUMAN

Locations in the PathwayBrowser for interactor IntAct:EBI-15634422 H3K9-2

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter (Homo sapiens)
        
        MPHOSPH8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99549 MPHOSPH8

Gene Names

MPHOSPH8, MPP8

Chain

chain:1-860

Reference Genes

BioGPS Gene:54737 MPHOSPH8

COSMIC (genes):MPHOSPH8 MPHOSPH8

CTD Gene:54737 MPHOSPH8

dbSNP Gene:54737 MPHOSPH8

ENSEMBL:ENSG00000196199 MPHOSPH8

HGNC:29810 MPHOSPH8

KEGG:hsa:54737 MPHOSPH8

Monarch:54737 MPHOSPH8

NCBI Gene:54737 MPHOSPH8

OMIM:611626 MPHOSPH8

UCSC:Q99549 MPHOSPH8

Reference Transcript

Other Identifiers

11734842_at

11734843_x_at

11734844_a_at

11746112_x_at

11763450_s_at

16772904

221771_PM_s_at

221771_s_at

225041_PM_at

225041_at

227026_PM_at

227026_at

3442692

3442693

3442694

3442695

3442696

3442698

3480021

3480022

3480023

3480024

3480025

3480032

3480033

3480034

3480035

3480038

3480042

3480043

3480044

3480045

3480046

3480047

3480048

3480049

3480050

3480052

3480054

3480056

3480057

3480060

3480061

3480062

3480063

3480064

3480065

3480066

3480067

3480068

3480079

35110_at

54737

57834_at

7967881

90596_at

A_14_P132052

A_14_P200363

A_23_P204967

A_24_P188183

A_24_P287403

GE85979

GO:0000786

GO:0000792

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006325

GO:0044027

GO:0045814

GO:0062072

GO:0140719

GO:0141005

HMNXSV003007957

Hs.244482.0.S1_3p_at

Hs.244482.1.A1_3p_at

Hs.244482.1.A2_3p_a_at

ILMN_2054213

PH_hs_0024869

TC13000017.hg

Participates

as a component of

as an input of

ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter (Homo sapiens)

Inferred To

MPHOSPH8 [nucleoplasm] (Bos taurus)

MPHOSPH8 [nucleoplasm] (Gallus gallus)

Ghost homologue of MPHOSPH8 [nucleoplasm] (Canis familiaris)

Ghost homologue of MPHOSPH8 [nucleoplasm] (Danio rerio)

Ghost homologue of MPHOSPH8 [nucleoplasm] (Sus scrofa)

mphosph8 [nucleoplasm] (Xenopus tropicalis)

Mphosph8 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_059990.2, XP_047286352.1, XP_054230589.1, XP_054230588.1

ENSEMBL

ENSP00000355388, ENST00000361479, ENSG00000196199

OpenTargets

ENSG00000196199

GeneCards

MPHOSPH8

HPA

ENSG00000196199-MPHOSPH8

PRO

Q99549

Pharos - Targets

Q99549

PDB

3R93, 6V2S, 3SVM, 3QO2, 8QFB, 3LWE, 7M5U

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.564	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.564	3
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.558	5
UniProt:Q9UK61 TASOR	1	TASOR [nucleoplasm] (R-HSA-9844031)	0.499	3
IntAct:EBI-15634422 H3K9-2			0.499	2

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