Reactome | Kinesin-7 is a dimer

Kinesin-7 is a dimer

Stable Identifier

R-HSA-984689

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Human kinesin-7, or CENP-E was one of the first kinesins to be discovered (Yen et al. 1991). It is essential for mammalian development, having a role in stabilizing kinetochore-microtubule capture (Putkey et al. 2002), CENP-E is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules and localizes to kinetochores throughout all phases of mitotic chromosome movement (early premetaphase through anaphase A). Though originally reported to be minus-end-directed it is now believed to be a plus-end-directed dimeric kinesin (Espeut et al. 2008). It is sequestered in the cytoplasm until nuclear envelope breakdown and then localizes to its chromosomal cargo at the kinetochores (Brown et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
18342609	Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E Gaussen, A, Espeut, J, Fesquet, D, Abrieu, A, Prieto, S, Surrey, T, Bieling, P, Morin, V	Mol Cell	2008