STAT3, DNMT1 and HDAC1 bind PTPN6 gene

Stable Identifier
R-HSA-9851071
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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STAT3, DNMT1 and HDAC1 bind PTPN6 gene
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STAT3, HDAC1 and DNMT1 bind to the PTPN6 promoter as assessed by electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP). Binding is mediated by interaction of active STAT3 with its cognate sites in the PTPN6 promoter (Zhang et al, 2005).
Binding of the STAT3:HDAC1:DNMT1 complex contributes to PTPN6 gene silencing in cutaneous T-cell lymphomas and ALK+ T-cell lymphomase. DNMT1 methyltransferase activity contributes to silencing by methylating CpG islands in the PTPN6 promoter; the exact role of HDAC1 has not been elucidated (Zhang et al, 2005).
Literature References
PubMed ID Title Journal Year
15870198 STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

Wasik, MA, Zhang, Q, Wang, HY, Marzec, M, Raghunath, PN, Nagasawa, T

Proc Natl Acad Sci U S A 2005
Participants
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Output
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
cutaneous T cell lymphoma DOID:0060061 cutaneous T-cell lymphoma
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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