JUNB- and NPM1-ALK-mediated GZMB gene expression

Stable Identifier
R-HSA-9851088
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytolytic granule lumen
ReviewStatus
5/5
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JUNB- and NPM1-ALK-mediated GZMB gene expression
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Granzyme B (GZMB) is a member of a family of 5 cytotoxic GZMB protein that contribute to cell death in response to cancer and infection (reviewed in Arias et al, 2017; Tibbs and Cao, 2022). GZMB is expressed in NPM1-ALK cells in a manner that depends on JUNB binding to cognate sites in its promoter (Pearson et al, 2011).
Literature References
PubMed ID Title Journal Year
35326588 Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease

Tibbs, E, Cao, X

Cancers (Basel) 2022
21326808 NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma

Pearson, JD, Lee, JK, Bacani, JT, Lai, R, Ingham, RJ

Int J Clin Exp Pathol 2011
28718416 The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances

Arias, M, Martínez-Lostao, L, Santiago, L, Ferrandez, A, Granville, DJ, Pardo, J

Trends Cancer 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GZMB gene:JUNB dimer [nucleoplasm] (Homo sapiens)
Active Unit
JUNB [nucleoplasm]
Disease
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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