NPM1-ALK- and p-STAT3-dependent IRF4 gene expression

Stable Identifier
Reaction [omitted]
Homo sapiens
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STAT3 binds to the IRF4 promoter downstream of NPM-ALK to promote IRF4 gene expression (Bandini et al, 2018; Marzec et al, 2013; Piva et al, 2010; Kasprzycka et al, 2006; Durant et al, 2010). IRF4 is a member of the interferon regulatory factor family of transcription factors that is expressed in immune cells response to activation of T-cell or B-cell receptors, IL-4 and CD40 signaling (reviewed in Wong et al, 2022). IRF4 expression downstream of NPM-ALK signaling is required for proliferation and survival, possibly through induction of MYC gene expression (Bandini et al, 2018; Weilemann et al, 2015).
Literature References
PubMed ID Title Journal Year
24218456 Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

Wasik, MA, Zhang, Q, Marzec, M, Ødum, N, Cheng, M, Liu, X, Schuster, SJ, Tobias, JW, Turner, SD, Wang, HY, Woetmann, A, Baldwin, D, Halasa, K

J Immunol 2013
20159827 Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms

De Wolf-Peeters, C, Piva, R, Inghirami, G, Facchetti, F, Rosenwald, A, Fornari, A, Pileri, S, Martinoglio, B, Piccaluga, PP, Geissinger, E, Medico, E, Pellegrino, E, Todoerti, K, Ponzoni, M, Neri, A, Müller-Hermelink, HK, Zamo, A, Agnelli, L, Grosso, V, Tamagno, I

J Clin Oncol 2010
20493732 Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis

Sun, HW, Durant, L, O'Shea, JJ, Laurence, A, Kanno, Y, Ramos, HL, Powrie, F, Watford, WT, Wei, L, Takahashi, H, Vahedi, G

Immunity 2010
16766651 Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

Liu, X, Wasik, MA, Zhang, Q, Marzec, M, Kasprzycka, M

Proc Natl Acad Sci U S A 2006
25359993 Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma

Madle, H, Anagnostopoulos, I, Lenz, P, Hayford, C, Lenz, G, Dörken, B, Siegert, A, Emre, NC, Tzankov, A, Rosenwald, A, Weilemann, A, Wollert-Wulf, B, Sobhiafshar, U, Janz, M, Erdmann, T, Fichtner, I, Ott, G, Mathas, S, Dirnhofer, S, Grau, M, Merkel, O, Hummel, M

Blood 2015
36077849 IRF4 as an Oncogenic Master Transcription Factor

Sanda, T, Theardy, MS, Ong, JZL, Wong, RWJ

Cancers (Basel) 2022
29346274 IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas

Duval, C, Piva, R, Bandini, C, Di Cunto, F, Pupuleku, A, Inghirami, G, Vitale, N, Cantarella, D, Provero, P, Medico, E, Pellegrino, E, Wang, R, Bertoni, F, Spaccarotella, E, Rinaldi, A

Cancers (Basel) 2018
This event is regulated
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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