Reactome | LipoH2-K110-DLST [mitochondrial matrix]

LipoH2-K110-DLST [mitochondrial matrix]

Stable Identifier

R-HSA-9853485

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

alpha-ketoglutarate dehydrogenase E2, DLST, Dihydrolipoamide succinyltransferase

Locations in the PathwayBrowser for interactor UniProt:O75175 CNOT3

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External Reference Information

External Reference

UniProt:P36957 DLST

Gene Names

DLST, DLTS

Chain

transit peptide:1-67, chain:68-453

Reference Genes

BioGPS Gene:1743 DLST

COSMIC (genes):DLST DLST

CTD Gene:1743 DLST

dbSNP Gene:1743 DLST

ENSEMBL:ENSG00000119689 DLST

HGNC:2911 DLST

KEGG:hsa:1743 DLST

Monarch:1743 DLST

NCBI Gene:1743 DLST

OMIM:126063 DLST

UCSC:P36957 DLST

Reference Transcript

RefSeq:NM_001933.4 DLST

Other Identifiers

11720929_a_at

11720930_s_at

11720931_x_at

11720932_s_at

11748080_a_at

11751226_x_at

11761177_at

16786524

1743

215210_PM_s_at

215210_s_at

2418675

2418678

2418682

2418684

2418687

2418688

33257_at

33258_g_at

3544349

3544350

3544351

3544352

3544353

3544354

3544355

3544356

3544357

3544358

3544360

3544361

3544362

3544363

3544364

3544365

3544367

3544368

3544369

3544370

3544372

3544373

3544374

3544375

3544376

3544377

3544378

3544379

3544380

3544381

45545_at

7975747

A_14_P109426

A_24_P13572

D26535_s_at

GE61495

GO:0003824

GO:0004149

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006091

GO:0006099

GO:0006103

GO:0006104

GO:0006520

GO:0006790

GO:0016020

GO:0016740

GO:0016746

GO:0033512

GO:0043226

GO:0045252

GO:0055086

GO:0140096

GO:0160167

GO:1901135

HMNXSV003018081

HMNXSV003048834

Hs.296348.0.S1_3p_s_at

ILMN_1773228

PH_hs_0029663

PH_hs_0032549

TC14000465.hg

TC14001772.hg

Participates

as an input of

as an output of

Other forms of this molecule

Lipo-K110-DLST [mitochondrial matrix]

SuccinyllipoH2-K110-DLST [mitochondrial matrix]

DLST [mitochondrial matrix]

GlutaryllipoH2-K110-DLST [mitochondrial matrix]

Inferred To

KGD2 [mitochondrial matrix] (Saccharomyces cerevisiae)

LipoH2-K110-DLST [mitochondrial matrix] (Plasmodium falciparum)

odhB [mitochondrial matrix] (Dictyostelium discoideum)

dlst-1 [mitochondrial matrix] (Caenorhabditis elegans)

DLST [mitochondrial matrix] (Bos taurus)

DLST [mitochondrial matrix] (Canis familiaris)

DLST [mitochondrial matrix] (Gallus gallus)

DLST [mitochondrial matrix] (Sus scrofa)

Dlst [mitochondrial matrix] (Drosophila melanogaster)

Dlst [mitochondrial matrix] (Mus musculus)

Dlst [mitochondrial matrix] (Rattus norvegicus)

kgd2 [mitochondrial matrix] (Schizosaccharomyces pombe)

dlst [mitochondrial matrix] (Danio rerio)

dlst [mitochondrial matrix] (Xenopus tropicalis)

Modified Residues

Name

N6-lipoyl-L-lysine ((R)-N6-dihydrolipoyl-L-lysine residue) at 110

Coordinate

110

Modification

(R)-N6-dihydrolipoyl-L-lysine residue

PsiMod Name

N6-lipoyl-L-lysine [MOD:00127]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.

Cross References

RefSeq

NP_001924.2

OpenTargets

ENSG00000119689

ENSEMBL

ENSP00000335304, ENST00000334220

IntEnz

2.3.1.61

HPA

ENSG00000119689-DLST

PRO

P36957

Pharos - Targets

P36957

GlyGen

P36957

HMDB Protein

HMDBP00939

PDB

6H05

Interactors (81)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.666	5
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q68CL5-3 TPGS2			0.556	3
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q9NX07 TSAP1			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
IntAct:EBI-25833913 CCSB			0.556	3
UniProt:Q3SY56 SP6			0.556	3
IntAct:EBI-25831691 CCSB			0.556	3
UniProt:Q96E17 RAB3C	2	GGC-RAB3C [cytosol] (R-HSA-8874012) RAB3C [cytosol] (R-HSA-8873684)	0.556	3
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q7Z780 Q7Z780			0.556	3
UniProt:Q96GK7 FAH2A			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q96L03 SPT17			0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:F6Y2X3 F6Y2X3			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q8N1W1-4 ARHGEF28			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P14060 HSD3B1	1	HSD3B1 [endoplasmic reticulum membrane] (R-HSA-192072)	0.556	3
UniProt:P79483 HLA-DRB3	9	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130513) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130432) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane] (R-HSA-2214381) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane] (R-HSA-2130452) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane] (R-HSA-2130559) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130515) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane] (R-HSA-2130377) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (R-HSA-2130676) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane] (R-HSA-197577)	0.556	3
UniProt:Q6P4D5-2 PABIR3			0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [nucleoplasm] (R-HSA-2564700) TPX2 [cytosol] (R-HSA-8853407)	0.556	3
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:O75317 USP12	1	USP12 [nucleoplasm] (R-HSA-5696907)	0.556	3
IntAct:EBI-25834143 CCSB			0.556	3
IntAct:EBI-25833532 RZPDO839F06154			0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.556	3
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8IY82 DRC7			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q96P20 NLRP3	2	NLRP3 [cytosol] (R-HSA-561189) K63polyUb-NLRP3 [cytosol] (R-HSA-6783288)	0.556	3
IntAct:EBI-25833762 CCSB			0.556	3
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P50749 RASF2			0.556	3
UniProt:Q8NCF5-2 NFATC2IP			0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:O14829 PPEF1	1	PPEF1 [cytosol] (R-HSA-2632517)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:Q9Y3Y4 PYGO1	1	PYGO1 [nucleoplasm] (R-HSA-201705)	0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:O00214-2 LGALS8			0.556	3
UniProt:A0JP07 A0JP07			0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.556	3
UniProt:Q96EY8 MMAB	4	MMAB E193K [mitochondrial matrix] (R-HSA-3322150) MMAB R191W [mitochondrial matrix] (R-HSA-3322112) MMAB R186W [mitochondrial matrix] (R-HSA-3322128) MMAB [mitochondrial matrix] (R-HSA-2980970)	0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.556	3
UniProt:O75874 IDH1	10	IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132H mutant [cytosol] (R-HSA-880015)	0.556	3
UniProt:P55209 NP1L1			0.547	3
UniProt:P09622 DLD	8	DLD [mitochondrial matrix] (R-HSA-69978) M361V DLD [mitochondrial matrix] (R-HSA-9907714) I393T DLD [mitochondrial matrix] (R-HSA-9907713) E375K DLD [mitochondrial matrix] (R-HSA-9907711) R495G DLD [mitochondrial matrix] (R-HSA-9907710) G229C DLD [mitochondrial matrix] (R-HSA-9907709) D479V DLD [mitochondrial matrix] (R-HSA-9907708) I47T DLD [mitochondrial matrix] (R-HSA-9907707)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.499	4
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.499	3
UniProt:Q9H9B4 SFXN1			0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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