Regulation of MITF-M dependent genes involved in metabolism

Stable Identifier
R-HSA-9854907
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Regulation of MITF-M dependent genes involved in metabolism
Click the image above or here to open this pathway in the Pathway Browser
MITF contributes to cellular energetics by regulating the expression of genes such as PPARGC1A, a regulator of mitochondrial biogenesis. MITF-dependent PPARGC1A expression shifts cells towards oxidative phosphorylation (Haq et al, 2013; Vazquez et al, 2013). MITF also promotes the expression of SIRT1, an NAD-dependent deacetylase that acts as a rheostat for cellular energetics. SIRT1 contributes to proliferation and inhibition of senescence in part through its regulation of p300 (Ohanna et al, 2014; Bouras et al, 2005).
Literature References
PubMed ID Title Journal Year
24742694 SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells

Bertolotto, C, Bille, K, Davidson, I, Bonet, C, Allegra, M, Ohanna, M, Lacour, JP, Ballotti, R, Bahadoran, P

Oncotarget 2014
15632193 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

Sauve, AA, Gu, W, Perkins, ND, Hay, RT, Pestell, RG, Wang, F, Quong, AA, Bouras, T, Fu, M

J Biol Chem 2005
23416000 PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress

Widlund, HR, Bhalla, K, Spiegelman, BM, Puigserver, P, Girnun, G, Clish, CB, Lim, JH, Pierce, K, Granter, SR, Chim, H, Vazquez, F

Cancer Cell 2013
23477830 Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF

Andreu-Perez, P, Nellore, A, Hurley, AD, Song, JS, Edelman, H, Kung, AL, Rowe, GC, Yokoyama, S, Fisher, DE, Arany, Z, Shoag, J, Wargo, JA, Widlund, HR, Frederick, DT, Haq, R

Cancer Cell 2013
Participants
Events
Participates
as an event of
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Created
Rothfels, K  (2023-11-28)
Cite Us!