Reactome | SDHB [mitochondrial matrix]

SDHB [mitochondrial matrix]

Stable Identifier

R-HSA-9854983

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Succinate Dehydrogenase complex subunit B, Succinate dehydrogenase (ubiquinone) iron-sulfur protein, mitochondrial, Ip, Iron-sulfur subunit of complex II

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21912 SDHB

Gene Names

SDHB, SDH, SDH1

Chain

transit peptide:1-28, chain:29-280

Reference Genes

BioGPS Gene:6390 SDHB

COSMIC (genes):SDHB SDHB

CTD Gene:6390 SDHB

dbSNP Gene:6390 SDHB

ENSEMBL:ENSG00000117118 SDHB

HGNC:10681 SDHB

KEGG:hsa:6390 SDHB

Monarch:6390 SDHB

NCBI Gene:6390 SDHB

OMIM:185470 SDHB

UCSC:P21912 SDHB

Reference Transcript

RefSeq:NM_003000.3 SDHB

Other Identifiers

11720631_a_at

11720632_x_at

11745517_s_at

16682384

202675_3p_at

202675_PM_at

202675_at

2398790

2398791

2398798

2398799

2398800

2398801

2398805

2398806

2398807

2398808

2398811

2398812

2398813

2398814

2398816

2398817

2398818

2398819

35751_at

6390

7912928

A_23_P149649

GE60529

GO:0005515

GO:0005654

GO:0005739

GO:0005743

GO:0005759

GO:0005886

GO:0006091

GO:0006099

GO:0006105

GO:0006121

GO:0008177

GO:0009055

GO:0009060

GO:0016020

GO:0016491

GO:0022904

GO:0031966

GO:0042776

GO:0045273

GO:0046872

GO:0048039

GO:0051536

GO:0051537

GO:0051538

GO:0051539

GO:0055086

GO:1901135

HMNXSV003041951

Hs.64.1.S1_3p_s_at

ILMN_1667257

PH_hs_0000010

TC01002286.hg

U17886_at

g9257241_3p_s_at

Participates

as an input of

Transfer of Fe-S clusters to SDHB (Homo sapiens)

as a component of

SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHAF1:SDHAF3 [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

SDHB [mitochondrial inner membrane]

Inferred To

SDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

Sdhb [mitochondrial matrix] (Mus musculus)

Sdhb [mitochondrial matrix] (Rattus norvegicus)

sdhB [mitochondrial matrix] (Dictyostelium discoideum)

sdhb [mitochondrial matrix] (Danio rerio)

sdhb [mitochondrial matrix] (Xenopus tropicalis)

sdh2 [mitochondrial matrix] (Schizosaccharomyces pombe)

SDHB [mitochondrial matrix] (Bos taurus)

SDHB [mitochondrial matrix] (Canis familiaris)

SDHB [mitochondrial matrix] (Gallus gallus)

SDHB [mitochondrial matrix] (Plasmodium falciparum)

SDHB [mitochondrial matrix] (Sus scrofa)

sdhb-1 [mitochondrial matrix] (Caenorhabditis elegans)

SdhB [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

NP_002991.2

ENSEMBL

ENST00000375499, ENSP00000364649, ENSG00000117118

OpenTargets

ENSG00000117118

GeneCards

SDHB

HPA

ENSG00000117118-SDHB

PRO

P21912

Pharos - Targets

P21912

GlyGen

P21912

Orphanet

SDHB

HMDB Protein

HMDBP00193

PDB

7KCL, 7KLV, 7KCM, 7KLU, 8GS8

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.823	11
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-29) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.822	23
UniProt:A6NFY7 SDHAF1	1	SDHAF1 [mitochondrial matrix] (R-HSA-9854988)	0.793	13
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.662	8
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.662	9
UniProt:Q9NRP4 SDHAF3	1	SDHAF3 [mitochondrial matrix] (R-HSA-9855015)	0.643	4
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.596	5
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:P54098 POLG	1	POLG [mitochondrial matrix] (R-HSA-9913624)	0.527	2
UniProt:Q4G176 ACSF3	1	ACSF3 [mitochondrial matrix] (R-HSA-5696011)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2

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