Reactome | Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)

Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)

Stable Identifier

R-HSA-9855106

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)

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Calpain2 cleaves TLN1 (Talin-1) between amino acid residues 433 and 434 (inferred from mouse homologs). Endothelial cells contain Calpain1 (mu-Calpain) and Calpain2 (m-Calpain) (Fujitani et al. 1997, Zhang et al. 2017). Endothelial Calpain2 is activated by calcium in response to laminar shear stress and cleaves TLN1 and VCL (Vinculin) (Miyazaki et al. 2007, 2010) of the cytoskeleton to alter the shape of the endothelial cell such that its long axis becomes parallel with the fluid flow.

Literature References

PubMed ID	Title	Journal	Year
17596297	Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity Miyazaki, T, Honda, K, Ohata, H	Am J Physiol Cell Physiol	2007
32848880	Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts Aglialoro, F, Hofsink, N, Hofman, M, Brandhorst, N, van den Akker, E	Front Physiol	2020