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pT153 USF1 [nucleoplasm]
Stable Identifier
R-HSA-9855887
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Upstream stimulatory factor 1, USF1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
pT153 USF1 [nucleoplasm] (Homo sapiens)
pT153 USF1 dimer:TYR promoter [nucleoplasm] (Homo sapiens)
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
pT153 USF1 [nucleoplasm] (Homo sapiens)
USF1 is phosphorylated by p-MAPK14 (Homo sapiens)
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
pT153 USF1 [nucleoplasm] (Homo sapiens)
p-T153 USF1 dimer binds the TYR promoter (Homo sapiens)
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
pT153 USF1 [nucleoplasm] (Homo sapiens)
pT153 USF1 dimer:TYR promoter [nucleoplasm] (Homo sapiens)
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
pT153 USF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22415 USF1
Gene Names
USF1, BHLHB11, USF
Chain
chain:1-310
Reference Genes
BioGPS Gene:7391 USF1
COSMIC (genes):USF1 USF1
CTD Gene:7391 USF1
dbSNP Gene:7391 USF1
ENSEMBL:ENSG00000158773 USF1
ENSEMBL_homo_sapiens_GENE:ENSG00000158773.14 USF1
HGNC:12593 USF1
KEGG Gene (Homo sapiens):7391 USF1
Monarch:7391 USF1
NCBI Gene:7391 USF1
OMIM:191523 USF1
UCSC:P22415 USF1
Reference Transcript
RefSeq:NM_001276373.1 USF1
RefSeq:NM_007122.4 USF1
RefSeq:NM_207005.2 USF1
Other Identifiers
11732958_at
16695517
231768_PM_at
231768_at
2440519
2440520
2440521
2440522
2440524
2440525
2440527
2440529
2440530
2440531
2440533
2440534
2440535
2440536
2440537
2440539
2440541
2440542
2440546
7391
7921738
A_23_P23646
GE62464
GE79273
GO:0000430
GO:0000432
GO:0000785
GO:0000978
GO:0000981
GO:0001666
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005794
GO:0006351
GO:0006355
GO:0006357
GO:0009411
GO:0019086
GO:0019899
GO:0019901
GO:0032869
GO:0042060
GO:0042593
GO:0042802
GO:0042803
GO:0042826
GO:0043226
GO:0043425
GO:0043565
GO:0044877
GO:0045893
GO:0045944
GO:0045990
GO:0046982
GO:0046983
GO:0051918
GO:0055088
GO:0140110
GO:1990837
HMNXSV003032477
Hs.247842.0.S2_3p_at
ILMN_1777982
ILMN_2353240
PH_hs_0018550
TC01003413.hg
X55666_at
Participates
as a component of
pT153 USF1 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
USF1 [nucleoplasm]
Inferred To
phospho-Usf1 [nucleoplasm]
(Mus musculus)
phospho-pT153 USF1 [nucleoplasm]
(Gallus gallus)
phospho-usf1 [nucleoplasm]
(Danio rerio)
phospho-usf1 [nucleoplasm]
(Xenopus tropicalis)
phospho-USF1 [nucleoplasm]
(Bos taurus)
phospho-USF1 [nucleoplasm]
(Canis familiaris)
phospho-USF1 [nucleoplasm]
(Sus scrofa)
phospho-Usf [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 153
Coordinate
153
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_009053.1
,
NP_001263302.1
,
NP_996888.1
OpenTargets
ENSG00000158773
HPA
ENSG00000158773-USF1
GeneCards
P22415
Ensembl
ENSP00000357000
,
ENSP00000356999
,
ENST00000368020
,
ENST00000368021
,
ENSG00000158773
PRO
P22415
Pharos - Targets
P22415
PDB
1AN4
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15407 FOSL1
1
FOSL1 [nucleoplasm]
(R-HSA-9620405)
0.782
7
UniProt:Q15853 USF2
1
USF2 [nucleoplasm]
(R-HSA-9023564)
0.708
5
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.666
4
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.623
5
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.623
5
UniProt:Q02880 TOP2B
2
monoSUMO1-K-TOP2B [nucleoplasm]
(R-HSA-4641297)
TOP2B [nucleoplasm]
(R-HSA-4641359)
0.558
3
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.558
3
UniProt:P13010 XRCC5
4
XRCC5 [extracellular region]
(R-HSA-6806530)
XRCC5 [secretory granule lumen]
(R-HSA-6801297)
XRCC5 [cytosol]
(R-HSA-3134849)
XRCC5 [nucleoplasm]
(R-HSA-58274)
0.558
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P57077-4 MAP3K7CL
0.556
3
UniProt:P28838 AMPL
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q6FG41 Q6FG41
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.527
3
UniProt:Q15853-2 USF2
0.527
2
UniProt:Q9NR55 BATF3
0.527
2
IntAct:EBI-9515373 MLP-DSDNA PROBE
0.524
7
UniProt:Q9UKV0 HDAC9
1
HDAC9 [nucleoplasm]
(R-HSA-3004554)
0.462
3
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.462
2
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