HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter

Stable Identifier
R-HSA-9858647
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter
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CTNNB1-dependent expression of the G1/S cyclin CCND1 is repressed in melanoma cells by the repressor protein HINT1 and co-repressors HDAC1 and SIN3A. HINT1 co-immunoprecipitates with CTNNB1 in melanoma cells and is localized to the CCND1 promoter in vivo as assessed by ChIP. HINT1 interacts with SIN3A and HDAC1, and increased expression of HINT1 decreases cell proliferation and tumorigenicity of melanoma cells (Genovese et al, 2013).
Literature References
PubMed ID Title Journal Year
22647378 The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells

Sioletic, S, Sgambato, A, Cittadini, A, Rettino, A, Ghosh, P, Genovese, G, Li, H

Cell Cycle 2012
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Orthologous Events
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Bos taurus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Caenorhabditis elegans)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Canis familiaris)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Drosophila melanogaster)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Gallus gallus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Mus musculus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Rattus norvegicus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Sus scrofa)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Xenopus tropicalis)
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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