Binding of ATRA to TGFBR3 gene promoter

Stable Identifier
R-HSA-9860125
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Binding of ATRA to TGFBR3 gene promoter
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Retinoic acid enhances the expression of TGFBR3 (betaglycan) by regulating its transcription. TGFBR3 promoter has binding sites for RA receptor and same has been confirmed through luciferase assay conducted on C2C12 cells, a differentiating myoblast cellline (Lopez-Casillas et al, 2003). TGFBR3 expression is also found to increase in a dose dependent way in human nueroblastoma cells in response to retinoic acid (Cohen et ai, 1995).
Literature References
PubMed ID Title Journal Year
12399463 Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta

López-Casillas, F, Riquelme, C, Perez-Kato, Y, Ponce-Castaneda, MV, Osses, N, Esparza-Lopez, J, Gonzalez-Nunez, G, Cabello-Verrugio, C, Mendoza, V, Troncoso, V, Brandan, E

J Biol Chem 2003
7757990 Induction of transforming growth factor beta 1 and its receptors during all-trans-retinoic acid (RA) treatment of RA-responsive human neuroblastoma cell lines

Cohen, PS, Letterio, JJ, Gaetano, C, Chan, J, Matsumoto, K, Sporn, MB, Thiele, CJ

Cancer Res 1995
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Authored
Tiwari, K  (2023-07-25)
Created
Tiwari, K  (2024-01-31)
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