Reactome | Phosphorylation of PDPK1 on serine-241

Phosphorylation of PDPK1 on serine-241

Stable Identifier

R-HSA-9860796

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic calcium downstream of PIEZO1 and signaling through ATP:P2RY2 and Gq/11 activate the phosphorylation of PDPK1 (PDK1) on serine-241 (Jin et al. 2021). PDPK1 in vitro spontaneously auto-phosphorylates serine-241 (Gao and Harris 2006); however, which kinase acts in vivo is unknown. Full autophosphorylation of PDPK1 on serine-241 and threonine-513 occurs after PDPK1 has bound phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gao and Harris 2006); however, the activity of PI3K, a source of PIP3, is not required during activation of PDPK1 in response to shear flow (Jin et al. 2021)

Literature References

PubMed ID	Title	Journal	Year
34499618	Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation Jin, YJ, Chennupati, R, Li, R, Liang, G, Wang, S, Iring, A, Graumann, J, Wettschureck, N, Offermanns, S	J Clin Invest	2021
16780920	Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity Gao, X, Harris, TK	Bioorg Chem	2006