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p-S241-PDPK1 [cytosol]
Stable Identifier
R-HSA-9860799
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-phosphoinositide-dependent protein kinase 1, PDPK1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O75116 ROCK2
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Homo sapiens)
p-S241-PDPK1 [cytosol] (Homo sapiens)
Phosphorylation of PDPK1 on serine-241 (Homo sapiens)
p-S241-PDPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15530 PDPK1
Gene Names
PDPK1, PDK1
Chain
chain:1-556
Reference Genes
BioGPS Gene:5170 PDPK1
COSMIC (genes):PDPK1 PDPK1
CTD Gene:5170 PDPK1
dbSNP Gene:5170 PDPK1
ENSEMBL:ENSG00000140992 PDPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000140992.19 PDPK1
HGNC:8816 PDPK1
KEGG Gene (Homo sapiens):5170 PDPK1
Monarch:5170 PDPK1
NCBI Gene:5170 PDPK1
OMIM:605213 PDPK1
UCSC:O15530 PDPK1
Reference Transcript
RefSeq:NM_001261816.1 PDPK1
RefSeq:NM_031268.5 PDPK1
RefSeq:NM_002613.4 PDPK1
Other Identifiers
11719708_a_at
11719709_x_at
11719710_a_at
11719711_a_at
11756248_a_at
16823153
204524_PM_at
204524_at
224986_PM_s_at
224986_s_at
32029_PM_at
32029_at
3644975
3644985
3644987
3644988
3644989
3644991
3644997
3645000
3645001
3645002
3645004
3645005
3645006
3645007
3645008
3645009
3645010
3645011
3645012
3645013
3645014
3645015
3645016
3645017
3645018
3645022
3645099
3645101
3645102
3645103
3645104
3645117
3645211
3645215
3645216
3645217
3645252
3676981
3676982
3676983
3676985
3676994
3676996
3676998
3676999
3677000
3677049
3677050
3677051
3677054
3677064
3677066
3677073
3677075
3677076
4864258_3p_at
4864258_3p_x_at
5170
64052_at
73168_s_at
77710_at
7992670
7992678
7998825
A_14_P120883
A_14_P123854
A_14_P128757
A_23_P66219
A_24_P222599
A_24_P830690
GE54148
GO:0000166
GO:0002376
GO:0003323
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005925
GO:0006468
GO:0006469
GO:0006972
GO:0007010
GO:0007155
GO:0007173
GO:0008286
GO:0010518
GO:0010594
GO:0010667
GO:0012501
GO:0014069
GO:0016004
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018107
GO:0019722
GO:0023052
GO:0030036
GO:0030154
GO:0030512
GO:0031295
GO:0031410
GO:0032148
GO:0032869
GO:0034122
GO:0035556
GO:0036211
GO:0042995
GO:0043122
GO:0043226
GO:0043274
GO:0043304
GO:0043536
GO:0045766
GO:0046777
GO:0048009
GO:0048856
GO:0048870
GO:0051281
GO:0051897
GO:0055065
GO:0055085
GO:0070161
GO:0071364
GO:0072659
GO:0097191
GO:0098542
GO:0098772
GO:0106310
GO:0140096
GO:1903078
GO:1903672
GO:1905564
GO:2000352
HMNXSV003019159
HMNXSV003046190
HMNXSV003046750
Hs.25063.1.S1_3p_at
ILMN_1653793
ILMN_1773174
ILMN_1773758
ILMN_1810554
ILMN_2387799
PH_hs_0009318
PH_hs_0035616
TC16000787.hg
TC16001386.hg
g4505694_3p_at
g4505694_3p_s_at
Participates
as an output of
Phosphorylation of PDPK1 on serine-241 (Homo sapiens)
Other forms of this molecule
PDPK1 [cytosol]
PDPK1 [plasma membrane]
Inferred To
phospho-p-S241-PDPK1 [cytosol]
(Bos taurus)
phospho-p-S241-PDPK1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S241-PDPK1 [cytosol]
(Danio rerio)
phospho-p-S241-PDPK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S241-PDPK1 [cytosol]
(Drosophila melanogaster)
phospho-p-S241-PDPK1 [cytosol]
(Gallus gallus)
phospho-p-S241-PDPK1 [cytosol]
(Mus musculus)
phospho-p-S241-PDPK1 [cytosol]
(Plasmodium falciparum)
phospho-p-S241-PDPK1 [cytosol]
(Rattus norvegicus)
phospho-p-S241-PDPK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S241-PDPK1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S241-PDPK1 [cytosol]
(Sus scrofa)
phospho-p-S241-PDPK1 [cytosol]
(Xenopus tropicalis)
phospho-PDPK1 [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-serine at 241
Coordinate
241
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_112558.2
,
NP_001248745.1
,
NP_002604.1
ZINC - World Drugs
PDPK1_HUMAN
Guide to Pharmacology - Targets
1519
OpenTargets
ENSG00000140992
ZINC - FDA approved
PDPK1_HUMAN
ZINC - Substances
PDPK1_HUMAN
ZINC target
O15530
ZINC - Biogenic
PDPK1_HUMAN
PRO
O15530
PDB
3QC4
,
1Z5M
,
1H1W
,
1OKZ
,
3IOP
,
5HO7
,
5HNG
,
5LVL
,
3HRF
,
3HRC
,
3H9O
,
5LVM
,
3NUY
,
4RQV
,
1UU9
,
3ION
,
3QCQ
,
1UU7
,
5HKM
,
4A07
,
3QD4
,
4RRV
,
5LVP
,
3RWQ
,
4A06
,
4CT2
,
3QD3
,
3RCJ
,
3RWP
,
4CT1
,
8DQT
,
2XCH
,
2PE1
,
3QCY
,
4XX9
,
3QD0
,
1W1H
,
2PE0
,
3QCX
,
2VKI
,
1OKY
,
5HO8
,
1W1G
,
2R7B
,
3QCS
,
1UU8
,
1W1D
,
1UVR
,
5LVN
,
3NUU
,
5LVO
,
3NAY
,
3NAX
,
3OTU
,
3ORZ
,
3NUS
,
4RQK
,
4AW1
,
3ORX
,
5ACK
,
4AW0
,
1UU3
,
5MRD
,
3NUN
,
3SC1
,
6WJQ
,
3PWY
,
2XCK
,
2PE2
,
2BIY
ZINC - Investigational
PDPK1_HUMAN
ZINC - Metabolites
PDPK1_HUMAN
GeneCards
O15530
HPA
ENSG00000140992-PDPK1
Ensembl
ENST00000268673
,
ENST00000441549
,
ENSG00000140992
,
ENSP00000268673
,
ENST00000342085
,
ENSP00000344220
,
ENSP00000395357
Pharos - Targets
O15530
ZINC - Predictions - Purchasable
PDPK1_HUMAN
HMDB Protein
HMDBP01430
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.767
4
UniProt:Q9Y4P3 TBL2
0.623
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.564
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.544
3
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.527
3
UniProt:Q92896 GLG1
1
GLG1 [plasma membrane]
(R-HSA-2870220)
0.527
3
UniProt:P31431 SDC4
20
SDC4 [lysosomal lumen]
(R-HSA-2090041)
HS(6)-SDC4 [lysosomal lumen]
(R-HSA-2090058)
HS(1)-SDC4 [Golgi lumen]
(R-HSA-2076434)
HS(2)-SDC4 [Golgi lumen]
(R-HSA-2076411)
HS(3)-SDC4 [Golgi lumen]
(R-HSA-2076418)
HS(4)-SDC4 [Golgi lumen]
(R-HSA-2076407)
HS(6)-SDC4 [Golgi lumen]
(R-HSA-2076330)
HS(5)-SDC4 [Golgi lumen]
(R-HSA-2076510)
Heparan-SDC4 [Golgi lumen]
(R-HSA-2076374)
Heparan(1)-SDC4 [Golgi lumen]
(R-HSA-2076394)
Heparan(2)-SDC4 [Golgi lumen]
(R-HSA-2076446)
Heparan(4)-SDC4 [Golgi lumen]
(R-HSA-2076613)
Heparan(3)-SDC4 [Golgi lumen]
(R-HSA-2076460)
SDC4 [Golgi lumen]
(R-HSA-2054111)
XylS-SDC4 [Golgi lumen]
(R-HSA-2064195)
HS(4)-SDC4 [plasma membrane]
(R-HSA-2076670)
HS(6)-SDC4 [plasma membrane]
(R-HSA-2076633)
HS(2)-SDC4 [plasma membrane]
(R-HSA-2076694)
HS(1)-SDC4 [plasma membrane]
(R-HSA-2076653)
HS(3)-SDC4 [plasma membrane]
(R-HSA-2076674)
0.527
3
UniProt:O75116 ROCK2
2
ROCK2 [cytosol]
(R-HSA-419058)
Activated ROCK2 [cytosol]
(R-HSA-4687775)
0.527
2
UniProt:Q6A1A2 PDPK2
0.527
3
UniProt:O75487 GPC4
20
GPC4 [lysosomal lumen]
(R-HSA-2090030)
HS(6)-GPC4 [lysosomal lumen]
(R-HSA-2090073)
HS(1)-GPC4 [Golgi lumen]
(R-HSA-2076401)
HS(2)-GPC4 [Golgi lumen]
(R-HSA-2076336)
HS(3)-GPC4 [Golgi lumen]
(R-HSA-2076439)
HS(4)-GPC4 [Golgi lumen]
(R-HSA-2076368)
HS(6)-GPC4 [Golgi lumen]
(R-HSA-2076538)
HS(5)-GPC4 [Golgi lumen]
(R-HSA-2076488)
Heparan-GPC4 [Golgi lumen]
(R-HSA-2076475)
Heparan(1)-GPC4 [Golgi lumen]
(R-HSA-2076560)
Heparan(2)-GPC4 [Golgi lumen]
(R-HSA-2076555)
Heparan(4)-GPC4 [Golgi lumen]
(R-HSA-2076440)
HS(4)-GPC4 [plasma membrane]
(R-HSA-2076638)
HS(6)-GPC4 [plasma membrane]
(R-HSA-2076677)
HS(2)-GPC4 [plasma membrane]
(R-HSA-2076662)
HS(1)-GPC4 [plasma membrane]
(R-HSA-2076673)
HS(3)-GPC4 [plasma membrane]
(R-HSA-2076697)
HS(5)-GPC4 [plasma membrane]
(R-HSA-2076658)
Gal-Gal-Xyl-GPC4 [Golgi lumen]
(R-HSA-2064030)
GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen]
(R-HSA-2064215)
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.527
3
UniProt:Q9BZF1 OSBPL8
1
OSBPL8 [cytosol]
(R-HSA-8867870)
0.527
2
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.527
3
UniProt:P35052 GPC1
20
GPC1 [lysosomal lumen]
(R-HSA-2090044)
HS(6)-GPC1 [lysosomal lumen]
(R-HSA-2090035)
HS(1)-GPC1 [Golgi lumen]
(R-HSA-2076424)
HS(2)-GPC1 [Golgi lumen]
(R-HSA-2076296)
HS(3)-GPC1 [Golgi lumen]
(R-HSA-2076340)
HS(4)-GPC1 [Golgi lumen]
(R-HSA-2076502)
HS(6)-GPC1 [Golgi lumen]
(R-HSA-2076531)
HS(5)-GPC1 [Golgi lumen]
(R-HSA-2076288)
Heparan-GPC1 [Golgi lumen]
(R-HSA-2076567)
Heparan(1)-GPC1 [Golgi lumen]
(R-HSA-2076476)
Heparan(2)-GPC1 [Golgi lumen]
(R-HSA-2076501)
Heparan(4)-GPC1 [Golgi lumen]
(R-HSA-2076605)
Heparan(3)-GPC1 [Golgi lumen]
(R-HSA-2076503)
GPC1 [Golgi lumen]
(R-HSA-2054106)
HS(4)-GPC1 [plasma membrane]
(R-HSA-2076668)
HS(6)-GPC1 [plasma membrane]
(R-HSA-2076629)
HS(2)-GPC1 [plasma membrane]
(R-HSA-2076632)
HS(1)-GPC1 [plasma membrane]
(R-HSA-2076645)
HS(3)-GPC1 [plasma membrane]
(R-HSA-2076636)
HS(5)-GPC1 [plasma membrane]
(R-HSA-2076648)
0.527
2
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
4
UniProt:P18827 SDC1
20
SDC1 [plasma membrane]
(R-HSA-174758)
SDC1 [lysosomal lumen]
(R-HSA-2090025)
HS(6)-SDC1 [lysosomal lumen]
(R-HSA-2090082)
HS(1)-SDC1 [Golgi lumen]
(R-HSA-2076321)
HS(2)-SDC1 [Golgi lumen]
(R-HSA-2076309)
HS(3)-SDC1 [Golgi lumen]
(R-HSA-2076444)
HS(4)-SDC1 [Golgi lumen]
(R-HSA-2076593)
HS(6)-SDC1 [Golgi lumen]
(R-HSA-2076520)
HS(5)-SDC1 [Golgi lumen]
(R-HSA-2076290)
Heparan-SDC1 [Golgi lumen]
(R-HSA-2076561)
Heparan(1)-SDC1 [Golgi lumen]
(R-HSA-2076349)
Heparan(2)-SDC1 [Golgi lumen]
(R-HSA-2076558)
Heparan(4)-SDC1 [Golgi lumen]
(R-HSA-2076339)
Heparan(3)-SDC1 [Golgi lumen]
(R-HSA-2076314)
SDC1 [Golgi lumen]
(R-HSA-2054105)
XylS-SDC1 [Golgi lumen]
(R-HSA-2064146)
Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064148)
HS(4)-SDC1 [plasma membrane]
(R-HSA-2076693)
HS(6)-SDC1 [plasma membrane]
(R-HSA-2076652)
HS(2)-SDC1 [plasma membrane]
(R-HSA-2076666)
0.527
3
UniProt:O00468 AGRN
20
AGRN(30-2045) [lysosomal lumen]
(R-HSA-2090057)
HS(6)-AGRN [lysosomal lumen]
(R-HSA-2090081)
HS(1)-AGRN [Golgi lumen]
(R-HSA-2076350)
HS(2)-AGRN [Golgi lumen]
(R-HSA-2076521)
HS(3)-AGRN [Golgi lumen]
(R-HSA-2076493)
HS(4)-AGRN [Golgi lumen]
(R-HSA-2076337)
HS(6)-AGRN [Golgi lumen]
(R-HSA-2076568)
HS(5)-AGRN [Golgi lumen]
(R-HSA-2076606)
Heparan-AGRN [Golgi lumen]
(R-HSA-2076530)
Heparan(1)-AGRN [Golgi lumen]
(R-HSA-2076317)
Heparan(2)-AGRN [Golgi lumen]
(R-HSA-2076301)
Heparan(4)-AGRN [Golgi lumen]
(R-HSA-2076300)
Heparan(3)-AGRN [Golgi lumen]
(R-HSA-2076569)
AGRN(30-2045) [Golgi lumen]
(R-HSA-2054104)
XylS-AGRN(30-2045) [Golgi lumen]
(R-HSA-2064220)
Gal-Xyl-AGRN [Golgi lumen]
(R-HSA-2064130)
HS(4)-AGRN [plasma membrane]
(R-HSA-2076654)
HS(6)-AGRN [plasma membrane]
(R-HSA-2076678)
HS(2)-AGRN [plasma membrane]
(R-HSA-2076686)
HS(1)-AGRN [plasma membrane]
(R-HSA-2076634)
0.527
2
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:P09038 FGF2
1
FGF2(10-155) [extracellular region]
(R-HSA-189898)
0.527
2
UniProt:Q00005 2ABB
0.524
8
UniProt:O95704 APBB3
0.488
2
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.488
2
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