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VCL(95 kDa) [cytosol]
Stable Identifier
R-HSA-9861471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Vinculin, VINC_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P62979 RPS27A
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
VCL(95 kDa) [cytosol] (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
VCL(95 kDa) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18206 VCL
Gene Names
VCL
Chain
chain:1-1134
Reference Genes
COSMIC (genes):VCL VCL
dbSNP Gene:7414 VCL
ENSEMBL:ENSG00000035403 VCL
Participates
as an output of
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
Other forms of this molecule
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
VCL [ficolin-1-rich granule lumen]
VCL [secretory granule lumen]
VCL [extracellular region]
VCL [specific granule lumen]
VCL [cytosol]
Inferred To
Vinc [cytosol]
(Drosophila melanogaster)
fip-2 [cytosol]
(Dictyostelium discoideum)
deb-1 [cytosol]
(Caenorhabditis elegans)
Vcl [cytosol]
(Mus musculus)
Vcl [cytosol]
(Rattus norvegicus)
vcla [cytosol]
(Danio rerio)
VCL [cytosol]
(Bos taurus)
VCL [cytosol]
(Canis familiaris)
VCL [cytosol]
(Gallus gallus)
VCL [cytosol]
(Sus scrofa)
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18010 IPAA
0.758
7
UniProt:Q6XVZ2 Q6XVZ2
0.719
4
UniProt:B0BXR4 B0BXR4
0.65
6
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
9
UniProt:Q62417-2 SORBS1
0.591
3
UniProt:Q969V4 TEKT1
0.556
3
UniProt:Q9NYB9 ABI2
2
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
ABI2 [cytosol]
(R-HSA-1671647)
0.553
3
UniProt:Q15654 TRIP6
0.553
2
UniProt:P35221 CTNNA1
2
CTNNA1 [plasma membrane]
(R-HSA-191735)
CTNNA1 [cytosol]
(R-HSA-191697)
0.527
2
UniProt:Q9Y490 TLN1
4
TLN1 [extracellular region]
(R-HSA-350693)
TLN1(434-2541) [cytosol]
(R-HSA-9855156)
TLN1(1-433) [cytosol]
(R-HSA-9855031)
TLN1 [cytosol]
(R-HSA-350713)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62979 RPS27A
20
RPS27A(1-76) [endocytic vesicle membrane]
(R-HSA-939208)
RPS27A(77-156) [nucleoplasm]
(R-HSA-6798734)
Ub-33-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783024)
Ub-63-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783200)
Ub-6-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783040)
Ub-11-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783085)
Ub-48-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783075)
Ub-29-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783146)
Ub-63-RPS27A(1-76) [cytosol]
(R-HSA-939248)
RPS27A(1-76) [lysosomal lumen]
(R-HSA-9660001)
RPS27A(1-76) [cytosol]
(R-HSA-939205)
p-S65-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834951)
Ub-48-RPS27A(1-76) [cytosol]
(R-HSA-939202)
RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834993)
RPS27A(1-76) [late endosome lumen]
(R-HSA-9660022)
Ub-6-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782608)
Ub-63-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782503)
Ub-48-RPS27A(1-76) [nucleoplasm]
(R-HSA-5683037)
RPS27A(1-76) [nucleoplasm]
(R-HSA-939849)
Ub-11-RPS27A(1-76) [cytosol]
(R-HSA-3095933)
0.527
2
UniProt:Q7Z4L5 TTC21B
2
TTC21B [ciliary tip]
(R-HSA-5625349)
TTC21B [cilium]
(R-HSA-5610430)
0.508
2
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