Reactome | p-S336-ME1 [cytosol]

p-S336-ME1 [cytosol]

Stable Identifier

R-HSA-9861606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NADP-dependent malic enzyme, MAOX_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48163 ME1

Gene Names

ME1

Chain

chain:1-572

Reference Genes

BioGPS Gene:4199 ME1

COSMIC (genes):ME1 ME1

CTD Gene:4199 ME1

dbSNP Gene:4199 ME1

ENSEMBL:ENSG00000065833 ME1

ENSEMBL_homo_sapiens_GENE:ENSG00000065833.9 ME1

HGNC:6983 ME1

KEGG Gene (Homo sapiens):4199 ME1

Monarch:4199 ME1

NCBI Gene:4199 ME1

OMIM:154250 ME1

UCSC:P48163 ME1

Reference Transcript

Other Identifiers

11726265_at

11750913_a_at

17021217

204058_PM_at

204058_at

204059_PM_s_at

204059_s_at

2962821

2962822

2962823

2962824

2962825

2962826

2962827

2962828

2962829

2962831

2962837

2962847

2962849

2962850

2962858

2962859

2962868

2962869

31824_at

4199

8127854

837_s_at

A_23_P422026

A_23_P8196

GE57728

GO:0000287

GO:0003824

GO:0004470

GO:0004471

GO:0004473

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006090

GO:0006091

GO:0006108

GO:0006734

GO:0006739

GO:0008948

GO:0009055

GO:0009165

GO:0009725

GO:0009743

GO:0016491

GO:0016616

GO:0016829

GO:0022900

GO:0030145

GO:0042802

GO:0043226

GO:0043531

GO:0046872

GO:0050661

GO:0051287

GO:0051289

GO:0055086

GO:0065003

GO:1902031

HMNXSV003041291

Hs.14732.0.S2_3p_at

ILMN_1736042

PH_hs_0001390

TC06001912.hg

U43944_at

g13435400_3p_a_at

Participates

as an output of

NEK1 phosphorylates ME1 (Homo sapiens)

as an input of

PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)

This entity regulates

Negatively

ME1 tetramer decarboxylates MAL to PYR (Homo sapiens)

Other forms of this molecule

ME1 [cytosol]

Inferred To

phospho-p-S336-ME1 [cytosol] (Bos taurus)

phospho-p-S336-ME1 [cytosol] (Caenorhabditis elegans)

phospho-p-S336-ME1 [cytosol] (Canis familiaris)

phospho-p-S336-ME1 [cytosol] (Danio rerio)

phospho-p-S336-ME1 [cytosol] (Drosophila melanogaster)

phospho-p-S336-ME1 [cytosol] (Gallus gallus)

phospho-p-S336-ME1 [cytosol] (Mus musculus)

phospho-p-S336-ME1 [cytosol] (Rattus norvegicus)

phospho-p-S336-ME1 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 336

Coordinate

336

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011534138.1, NP_002386.1

OpenTargets

ENSG00000065833

ZINC - Substances

MAOX_HUMAN

GeneCards

P48163

HPA

ENSG00000065833-ME1

ZINC target

P48163

Ensembl

ENSP00000358719, ENST00000369705, ENSG00000065833

PRO

P48163

Pharos - Targets

P48163

ZINC - Predictions - Purchasable

MAOX_HUMAN

HMDB Protein

HMDBP00857

PDB

7X11, 2AW5, 3WJA, 7X12

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48163 ME1	2	p-S336-ME1 [cytosol] (R-HSA-9861606) ME1 [cytosol] (R-HSA-400119)	0.683	5
UniProt:P11498 PC	3	Btn-PC [cytosol] (R-HSA-3323170) PC [cytosol] (R-HSA-3323119) Btn-PC [mitochondrial matrix] (R-HSA-2993804)	0.668	14
UniProt:P40925 MDH1	1	MDH1 [cytosol] (R-HSA-198471)	0.62	11
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2