Reactome | p-Y393-ABL1 [cytosol]

p-Y393-ABL1 [cytosol]

Stable Identifier

R-HSA-9865161

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ABL1 ecNumber evidence="44 50"2.7.10.2, ABL1_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q8IZP0 ABI1

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External Reference Information

External Reference

UniProt:P00519 ABL1

Gene Names

ABL1, ABL, JTK7

Chain

chain:1-1130

Reference Genes

BioGPS Gene:25 ABL1

COSMIC (genes):ABL1 ABL1

CTD Gene:25 ABL1

dbSNP Gene:25 ABL1

ENSEMBL:ENSG00000097007 ABL1

ENSEMBL_homo_sapiens_GENE:ENSG00000097007.20 ABL1

HGNC:76 ABL1

KEGG Gene (Homo sapiens):25 ABL1

Monarch:25 ABL1

NCBI Gene:25 ABL1

OMIM:189980 ABL1

UCSC:P00519 ABL1

Reference Transcript

Other Identifiers

11717174_a_at

11717175_a_at

11740485_a_at

11757851_s_at

1635_at

1636_g_at

1656_s_at

17090373

202123_PM_s_at

202123_s_at

2040_s_at

2041_i_at

3191725

3191726

3191748

3191758

3191759

3191760

3191770

3191774

3191775

3191776

3191777

3191779

3191780

3191782

3191785

3191786

3191787

3191788

3191789

39730_at

52316_s_at

8158725

A_23_P60180

A_24_P281101

A_24_P282416

A_24_P291016

A_24_P393711

GE58357

GO:0000166

GO:0000278

GO:0000287

GO:0000400

GO:0000405

GO:0001726

GO:0001784

GO:0001843

GO:0001922

GO:0001934

GO:0002322

GO:0002333

GO:0002376

GO:0003013

GO:0003677

GO:0003713

GO:0003785

GO:0003824

GO:0004515

GO:0004672

GO:0004713

GO:0004715

GO:0005080

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0006281

GO:0006298

GO:0006310

GO:0006351

GO:0006355

GO:0006468

GO:0006897

GO:0006909

GO:0006914

GO:0006915

GO:0006974

GO:0006979

GO:0007010

GO:0007154

GO:0007155

GO:0007163

GO:0007173

GO:0007204

GO:0007229

GO:0007249

GO:0007611

GO:0008092

GO:0008306

GO:0008630

GO:0009410

GO:0009791

GO:0010506

GO:0010595

GO:0012501

GO:0015629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016604

GO:0016740

GO:0017124

GO:0018108

GO:0019901

GO:0019904

GO:0019905

GO:0021587

GO:0022408

GO:0023052

GO:0030035

GO:0030036

GO:0030041

GO:0030100

GO:0030145

GO:0030154

GO:0030155

GO:0030182

GO:0030198

GO:0030425

GO:0030426

GO:0030509

GO:0030514

GO:0030516

GO:0031113

GO:0031252

GO:0031965

GO:0032489

GO:0032729

GO:0032743

GO:0032956

GO:0032991

GO:0033690

GO:0034330

GO:0034446

GO:0034599

GO:0034976

GO:0035791

GO:0036211

GO:0038083

GO:0038096

GO:0038189

GO:0038191

GO:0042100

GO:0042127

GO:0042169

GO:0042770

GO:0042981

GO:0043025

GO:0043065

GO:0043123

GO:0043226

GO:0043525

GO:0043542

GO:0043621

GO:0045580

GO:0045907

GO:0045930

GO:0045931

GO:0045944

GO:0046632

GO:0046777

GO:0046872

GO:0046875

GO:0048008

GO:0048146

GO:0048471

GO:0048536

GO:0048538

GO:0048856

GO:0048870

GO:0050731

GO:0050798

GO:0050852

GO:0050853

GO:0050877

GO:0050885

GO:0051015

GO:0051019

GO:0051128

GO:0051281

GO:0051353

GO:0051402

GO:0051444

GO:0051450

GO:0051496

GO:0051649

GO:0051726

GO:0051882

GO:0051894

GO:0055065

GO:0055085

GO:0060020

GO:0060038

GO:0060563

GO:0065003

GO:0070064

GO:0070097

GO:0070301

GO:0070371

GO:0070373

GO:0070374

GO:0071103

GO:0071222

GO:0071560

GO:0071871

GO:0071901

GO:0072359

GO:0090050

GO:0090398

GO:0098609

GO:0098794

GO:0140096

GO:0140110

GO:1900006

GO:1900026

GO:1900272

GO:1900275

GO:1902036

GO:1903053

GO:1903055

GO:1903210

GO:1903351

GO:1903905

GO:1904157

GO:1904518

GO:1904528

GO:1904531

GO:1905244

GO:1905555

GO:1990051

GO:1990837

GO:2000042

GO:2000096

GO:2000145

GO:2000352

GO:2000406

GO:2000772

GO:2000773

HMNXSV003048474

ILMN_1708922

ILMN_1713732

ILMN_2268241

PH_hs_0021950

TC09000741.hg

TC09002302.hg

X16416_at

g6382056_3p_a_at

Participates

as an output of

Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Homo sapiens)

Other forms of this molecule

p-Y226,Y393-ABL1 [nucleoplasm]

ABL1 [cytosol]

p-Y226,Y393-ABL1 [cytosol]

ABL1 [nucleoplasm]

p-S456-ABL1 [nucleoplasm]

Inferred To

phospho-p-Y393-ABL1 [cytosol] (Bos taurus)

phospho-p-Y393-ABL1 [cytosol] (Caenorhabditis elegans)

phospho-p-Y393-ABL1 [cytosol] (Canis familiaris)

phospho-p-Y393-ABL1 [cytosol] (Drosophila melanogaster)

phospho-p-Y393-ABL1 [cytosol] (Gallus gallus)

phospho-p-Y393-ABL1 [cytosol] (Mus musculus)

phospho-p-Y393-ABL1 [cytosol] (Rattus norvegicus)

phospho-p-Y393-ABL1 [cytosol] (Sus scrofa)

phospho-p-Y393-ABL1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 393

Coordinate

393

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005148.2, NP_009297.2

ZINC - World Drugs

ABL1_HUMAN

Guide to Pharmacology - Targets

1923

OpenTargets

ENSG00000097007

ZINC - FDA approved

ABL1_HUMAN

ZINC - Substances

ABL1_HUMAN

ZINC target

P00519

ZINC - Biogenic

ABL1_HUMAN

PRO

P00519

PDB

2G1T, 1AWO, 2HYY, 3QRJ, 2FO0, 2HZ4, 4J9G, 6NPE, 7PVQ, 3QRI, 2E2B, 3EGU, 4JJC, 4JJB, 2HZI, 2G2F, 1BBZ, 7N9G, 4TWP, 5HU9, 3EG1, 5DC0, 6XRG, 4ZOG, 7W7X, 6AMW, 7PVR, 4XEY, 4J9E, 5OAZ, 7PVS, 2V7A, 3EG2, 5DC4, 4J9D, 3QRK, 2HIW, 4J9H, 4J9I, 6BL8, 7CC2, 6XR6, 1JU5, 3T04, 8SSN, 3CS9, 7W7Y, 8H7F, 5NP2, 4WA9, 8H7H, 2F4J, 1OPL, 3K2M, 1ZZP, 7PVV, 6NPV, 2G2I, 2GQG, 4J9C, 1AB2, 3EG0, 4J9B, 4JJD, 2G2H, 4YC8, 3PYY, 4J9F, 2HZ0, 6XR7, 2ABL, 3UYO, 5DC9, 3EG3, 6AMV, 5MO4, 2O88, 7PW2, 3UE4, 7DT2, 6NPU

ZINC - Investigational

ABL1_HUMAN

ZINC - Metabolites

ABL1_HUMAN

GeneCards

P00519

HPA

ENSG00000097007-ABL1

Ensembl

ENST00000318560, ENSP00000323315, ENSG00000097007, ENST00000372348, ENSP00000361423

Pharos - Targets

P00519

Orphanet

15062

ZINC - Predictions - Purchasable

ABL1_HUMAN

HMDB Protein

HMDBP01402

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.9	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.889	8
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.827	6
UniProt:O43196 MSH5	1	MSH5 [nucleoplasm] (R-HSA-912435)	0.819	10
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.786	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.763	6
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.744	5
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.743	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	4
IntAct:EBI-7094147 P41			0.713	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.708	4
UniProt:Q13315 ATM	5	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) ATM [nucleoplasm] (R-HSA-69484) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.704	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.667	5
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.656	4
UniProt:Q03468 ERCC6	2	Ub-ERCC6 [nucleoplasm] (R-HSA-6781853) ERCC6 [nucleoplasm] (R-HSA-54429)	0.655	8
UniProt:P15941-12 MUC1			0.645	4
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.641	3
IntAct:EBI-3946155 ABL-TIDE			0.609	5
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.602	3
UniProt:P15498 VAV1	5	p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323)	0.602	5
UniProt:Q9Y4G6 TLN2			0.602	3
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.602	7
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.591	6
UniProt:Q9Y6W5 WASF2	3	WASF2 [cytosol] (R-HSA-200972) p-Y150,S343,T346-WASF2 [cytosol] (R-HSA-2130179) p-Y150-WASF2 [cytosol] (R-HSA-2130193)	0.59	2
UniProt:Q38SD2 LRRK1			0.59	3
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.589	2
UniProt:O35158	1	Cdon [plasma membrane] (R-RNO-197892)	0.581	4
UniProt:Q92918 M4K1			0.573	3
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390) p-Y151-WASF1 [cytosol] (R-HSA-2029058)	0.571	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.558	2
UniProt:P51692 STAT5B	4	STAT5B [cytosol] (R-HSA-380737) p-Y699-STAT5B [cytosol] (R-HSA-507939) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-STAT5B [cytosol] (R-HSA-8983127)	0.558	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.544	2
UniProt:O60504-2 SORBS3			0.544	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.544	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.536	2
UniProt:P05107 ITGB2	4	ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [plasma membrane] (R-HSA-198010)	0.524	4
UniProt:Q4KMG0 CDON	1	CDON [plasma membrane] (R-HSA-197892)	0.524	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.524	2
UniProt:Q15464 SHB	2	SHB [cytosol] (R-HSA-4420213) pS-SHB [cytosol] (R-HSA-5228991)	0.524	5
IntAct:EBI-7319639 P41R			0.508	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.463	4

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