Reactome | TIMM21 [mitochondrial intermembrane space]

TIMM21 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-9865416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

C18orf55 (TIM21L), TIM21-like protein, mitochondrial, TI21L_HUMAN, C18orf55

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BVV7 TIMM21

Gene Names

TIMM21, C18orf55, TIM21, HSPC154

Chain

transit peptide:1-18, chain:19-248

Reference Genes

BioGPS Gene:29090 TIMM21

COSMIC (genes):TIMM21 TIMM21

CTD Gene:29090 TIMM21

dbSNP Gene:29090 TIMM21

ENSEMBL:ENSG00000075336 TIMM21

HGNC:25010 TIMM21

KEGG:hsa:29090 TIMM21

Monarch:29090 TIMM21

NCBI Gene:29090 TIMM21

OMIM:615180 TIMM21

UCSC:Q9BVV7 TIMM21

Reference Transcript

RefSeq:NM_014177.2 TIMM21

Other Identifiers

11721512_a_at

11757443_s_at

16853042

223180_PM_s_at

223180_s_at

223181_PM_at

223181_at

29090

3793589

3793590

3793594

3793595

3793596

3793597

3793598

3793599

3793600

3793601

3793602

3793603

3793604

3793605

3793606

3793607

3793608

3793609

3793611

64941_at

8021716

A_14_P103860

A_24_P74088

GE58568

GO:0003674

GO:0005515

GO:0005739

GO:0005743

GO:0005744

GO:0005758

GO:0006886

GO:0015031

GO:0016020

GO:0030150

GO:0031966

GO:0032981

GO:0033617

GO:0043226

GO:0055085

GO:0065003

HMNXSV003007706

HMNXSV003022735

ILMN_1748916

ILMN_2182531

PH_hs_0027067

TC18000246.hg

g12654148_3p_a_at

Participates

as an output of

MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Homo sapiens)

as a component of

TIMM21:COX4:COX5A:COX6C [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

TIMM21 [mitochondrial inner membrane]

Inferred To

Timm21 [mitochondrial intermembrane space] (Mus musculus)

Timm21 [mitochondrial intermembrane space] (Rattus norvegicus)

TIMM21 [mitochondrial intermembrane space] (Bos taurus)

TIMM21 [mitochondrial intermembrane space] (Caenorhabditis elegans)

TIMM21 [mitochondrial intermembrane space] (Canis familiaris)

TIMM21 [mitochondrial intermembrane space] (Gallus gallus)

TIMM21 [mitochondrial intermembrane space] (Sus scrofa)

timm21 [mitochondrial intermembrane space] (Xenopus tropicalis)

Dmel\CG7382 [mitochondrial intermembrane space] (Drosophila melanogaster)

tim21 [mitochondrial intermembrane space] (Schizosaccharomyces pombe)

TIM21 [mitochondrial intermembrane space] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000169551, ENST00000169551

OpenTargets

ENSG00000075336

HPA

ENSG00000075336-TIMM21

PRO

Q9BVV7

Pharos - Targets

Q9BVV7

GlyGen

Q9BVV7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:O14925 TIMM23	2	TIMM23 [mitochondrial intermembrane space] (R-HSA-1299436) TIMM23 [mitochondrial inner membrane] (R-HSA-1252126)	0.499	3

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