Reactome | 2Fe-2S is inserted in UQCRFS1

2Fe-2S is inserted in UQCRFS1

Stable Identifier

R-HSA-9866272

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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Frataxin (FXN) subunit of the 2Fe-2S transfer complex catalyzes the insertion of one 2Fe-2S cluster in the Complex III subunit UQCRFS1 (Rieske protein) as part of a UQCRFS1:LYRM7 complex. The process requires the presence of the co-chaperone complex HSPA9:HSCB (Maio et al., 2017; Fernandez-Vizarra & Zeviani, 2018).

Literature References

PubMed ID	Title	Journal	Year
29243944	Mitochondrial complex III Rieske Fe-S protein processing and assembly Fernandez-Vizarra, E, Zeviani, M	Cell Cycle	2018
28380382	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III Maio, N, Singh, A, Kim, KS, Rouault, TA	Cell Metab	2017