Reactome | nascent MT-CO2 [mitochondrial matrix]

nascent MT-CO2 [mitochondrial matrix]

Stable Identifier

R-HSA-9902095

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II

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Locations in the PathwayBrowser for interactor UniProt:P20674 COX5A

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External Reference Information

External Reference

UniProt:P00403 MT-CO2

Gene Names

MT-CO2, COII, COX2, COXII, MTCO2

Chain

chain:1-227

Reference Genes

BioGPS Gene:4513 MT-CO2

COSMIC (genes):MT-CO2 MT-CO2

CTD Gene:4513 MT-CO2

dbSNP Gene:4513 MT-CO2

ENSEMBL:ENSG00000198712 MT-CO2

HGNC:7421 MT-CO2

KEGG:hsa:4513 MT-CO2

Monarch:4513 MT-CO2

NCBI Gene:4513 MT-CO2

OMIM:516040 MT-CO2

UCSC:P00403 MT-CO2

Reference Transcript

RefSeq:NC_012920.1 MT-CO2

Other Identifiers

11758423_s_at

1553567_3p_s_at

1553567_PM_s_at

1553567_s_at

1553569_PM_at

1553569_at

1553570_PM_x_at

1553570_x_at

17100659

17100661

17100663

17126266

17126268

2315231

2315232

2315316

2315317

2315318

2315319

2492706

2492708

2868799

4037628

4037629

4037631

4037633

4037634

4037635

4037637

4037639

4037640

4037641

4037642

4037643

4037644

4513

7896750

7896752

8043375

8113356

8165663

8165665

8165667

A_23_P337726

A_23_P402751

A_33_P3410700

GO:0001666

GO:0003824

GO:0004129

GO:0005215

GO:0005507

GO:0005515

GO:0005739

GO:0005743

GO:0005759

GO:0006091

GO:0006123

GO:0007595

GO:0016020

GO:0016491

GO:0022900

GO:0031966

GO:0042773

GO:0043226

GO:0045277

GO:0045333

GO:0046872

GO:0055085

GO:1902600

HMNXSV003022003

HMNXSV003032141

HMNXSV003041642

Hs2Affx.1.41.S1_3p_s_at

Hs2Affx.1.43.S1_3p_x_at

PH_hs_0033947

PH_hs_0036541

RNA143496|tRNA_413_70

RNA143539|tRNA_456_68

TC01000013.hg

TC0M000005.hg

TC0M000021.hg

TC0M000022.hg

p26926

Participates

as an input of

COX18 inserts nascent MT-CO2 in COX20:TMEM77 (Homo sapiens)

as an output of

MT-CO2 mRNA is translated (Homo sapiens)

Other forms of this molecule

nascent MT-CO2 [mitochondrial inner membrane]

Inferred To

MT-CO2 [mitochondrial matrix] (Sus scrofa)

nascent MT-CO2 [mitochondrial matrix] (Bos taurus)

nascent MT-CO2 [mitochondrial matrix] (Danio rerio)

nascent MT-CO2 [mitochondrial matrix] (Drosophila melanogaster)

nascent MT-CO2 [mitochondrial matrix] (Gallus gallus)

nascent MT-CO2 [mitochondrial matrix] (Mus musculus)

nascent MT-CO2 [mitochondrial matrix] (Rattus norvegicus)

Cross References

ZINC - World Drugs

COX2_HUMAN

ENSEMBL

ENSP00000354876

OpenTargets

ENSG00000198712

ZINC - Substances

COX2_HUMAN

ZINC - Biogenic

COX2_HUMAN

ZINC target

P00403

PRO

P00403

GlyGen

P00403

PDB

5Z62, 3VRJ

ZINC - Metabolites

COX2_HUMAN

HPA

ENSG00000198712-MT-CO2

Pharos - Targets

P00403

Orphanet

MT-CO2

ZINC - Predictions - Purchasable

COX2_HUMAN

HMDB Protein

HMDBP07035

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.731	5
UniProt:P14854 COX6B1	1	COX6B1 [mitochondrial inner membrane] (R-HSA-164299)	0.564	3
UniProt:P09669 COX6C	2	COX6C(3-75) [mitochondrial intermembrane space] (R-HSA-9865411) COX6C(3-75) [mitochondrial inner membrane] (R-HSA-164298)	0.564	3
UniProt:P20674 COX5A	2	COX5A [mitochondrial intermembrane space] (R-HSA-9865415) COX5A [mitochondrial inner membrane] (R-HSA-164308)	0.564	3
UniProt:P14406 COX7A2	1	COX7A2 [mitochondrial inner membrane] (R-HSA-5336134)	0.564	3
UniProt:P15954 COX7C	1	COX7C [mitochondrial inner membrane] (R-HSA-164306)	0.564	3
UniProt:Q9NZ94-2 NLGN3			0.543	4
UniProt:P49281-3 SLC11A2			0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q15118 PDK1	1	PDK1 [mitochondrial matrix] (R-HSA-203944)	0.463	2

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