Reactome | PAAF1 [cytosol]

PAAF1 [cytosol]

Stable Identifier

R-HSA-9907973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasomal ATPase-associated factor 1, PAAF1_HUMAN, WD repeat-containing protein 71, WDR71, Yeast Rpn14 ortholog

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BRP4 PAAF1

Gene Names

PAAF1, WDR71

Chain

initiator methionine:1, chain:2-392

Reference Genes

BioGPS Gene:80227 PAAF1

COSMIC (genes):PAAF1 PAAF1

CTD Gene:80227 PAAF1

dbSNP Gene:80227 PAAF1

ENSEMBL:ENSG00000175575 PAAF1

HGNC:25687 PAAF1

KEGG:hsa:80227 PAAF1

Monarch:80227 PAAF1

NCBI Entrez Gene:80227 PAAF1

OMIM:619772 PAAF1

UCSC:Q9BRP4 PAAF1

Reference Transcript

Other Identifiers

11744819_a_at

11746213_a_at

11757930_s_at

1568702_PM_a_at

1568702_a_at

16728908

16728930

218957_PM_s_at

218957_s_at

3340065

3340067

3340068

3340069

3340071

3340072

3340073

3340078

3340079

3340080

3340081

3340083

3340084

3340085

3340088

3340089

3340092

3340093

3340095

3340096

3340098

3340099

3340100

3340105

3340106

3340108

3340109

3340111

50344_at

61748_at

7942476

80227

A_14_P128774

A_23_P139339

A_33_P3265075

A_33_P3374643

GE83111

GO:0000502

GO:0005515

GO:0005829

GO:0016020

HMNXSV003027654

HMNXSV003029803

Hs2.109021.1.A1_3p_s_at

ILMN_1652753

PH_hs_0024753

TC11000781.hg

TC11000782.hg

g13376750_3p_s_at

p2841

Participates

as an output of

as an input of

PSMD10 and PAAF1 bind PSMC4:PSMC5 (Homo sapiens)

as a component of

PSMD10:PSMC4:PSMC5:PAAF1 [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of PAAF1 [cytosol] (Bos taurus)

Ghost homologue of PAAF1 [cytosol] (Canis familiaris)

Ghost homologue of PAAF1 [cytosol] (Danio rerio)

Ghost homologue of PAAF1 [cytosol] (Gallus gallus)

Ghost homologue of PAAF1 [cytosol] (Mus musculus)

Ghost homologue of PAAF1 [cytosol] (Rattus norvegicus)

Ghost homologue of PAAF1 [cytosol] (Sus scrofa)

Ghost homologue of PAAF1 [cytosol] (Xenopus tropicalis)

taf-5 [cytosol] (Caenorhabditis elegans)

taf5 [cytosol] (Dictyostelium discoideum)

taf5 [cytosol] (Schizosaccharomyces pombe)

can [cytosol] (Drosophila melanogaster)

TAF5 [cytosol] (Saccharomyces cerevisiae)

Homologues of PAAF1 [cytosol] (Drosophila melanogaster)

Homologues of PAAF1 [cytosol] (Schizosaccharomyces pombe)

Taf5 [cytosol] (Drosophila melanogaster)

wda [cytosol] (Drosophila melanogaster)

taf73 [cytosol] (Schizosaccharomyces pombe)

PAAF1 [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_001254733.1, NP_001254732.1, NP_001254735.1, NP_001254734.1, NP_079431.1

OpenTargets

ENSG00000175575

ENSEMBL

ENST00000541951, ENST00000536003, ENSP00000441494, ENSG00000175575, ENSP00000441333, ENSP00000311665, ENSP00000365564, ENSP00000438124, ENSP00000438789, ENST00000535604, ENST00000376384, ENST00000310571, ENST00000544552

HPA

ENSG00000175575-PAAF1

GeneCards

PAAF1

PRO

Q9BRP4

Pharos - Targets

Q9BRP4

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.802	9
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.793	6
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.744	4
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.744	4
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.744	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.669	4
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.669	4
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.669	3
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.669	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	3
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	2
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.564	2
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.527	2

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