Reactome | pro-PSMB6 [cytosol]

pro-PSMB6 [cytosol]

Stable Identifier

R-HSA-9908130

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Precursor of proteasome subunit beta-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28072 PSMB6

Gene Names

PSMB6, LMPY, Y

Chain

initiator methionine:1, propeptide:2-34, chain:35-239

Reference Genes

BioGPS Gene:5694 PSMB6

COSMIC (genes):PSMB6 PSMB6

CTD Gene:5694 PSMB6

dbSNP Gene:5694 PSMB6

ENSEMBL:ENSG00000142507 PSMB6

HGNC:9543 PSMB6

KEGG:hsa:5694 PSMB6

Monarch:5694 PSMB6

NCBI Entrez Gene:5694 PSMB6

OMIM:600307 PSMB6

UCSC:P28072 PSMB6

Reference Transcript

RefSeq:NM_002798.3 PSMB6

Other Identifiers

11757696_a_at

16829885

208827_PM_at

208827_at

3707200

3707201

3707203

3707204

3707205

3707206

3707207

3707208

3707209

3707210

3707211

5694

8003953

941_at

A_14_P101714

A_23_P15705

D29012_at

GE560878

GO:0000502

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005839

GO:0006508

GO:0008233

GO:0016787

GO:0019774

GO:0030163

GO:0043161

GO:0045296

GO:0051603

GO:0070062

HMNXSV003023984

ILMN_1666409

PH_hs_0004444

PH_hs_0031333

TC17000052.hg

g12654058_3p_at

Participates

as an input of

as a component of

Other forms of this molecule

PSMB6 [cytosol]

PSMB6 [nucleoplasm]

PSMB6(1-34) [cytosol]

Inferred To

psmb6 [cytosol] (Danio rerio)

Psmb6l1 [cytosol] (Rattus norvegicus)

bpro-PSMB6 [cytosol] (Bos taurus)

PRE3 [cytosol] (Saccharomyces cerevisiae)

PSMB6 [cytosol] (Canis familiaris)

Psmb6 [cytosol] (Mus musculus)

Psmb6 [cytosol] (Rattus norvegicus)

pbs-1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of pro-PSMB6 [cytosol] (Sus scrofa)

pro-PSMB6 [cytosol] (Gallus gallus)

pro-PSMB6 [cytosol] (Plasmodium falciparum)

Prosbeta1 [cytosol] (Drosophila melanogaster)

psmB6 [cytosol] (Dictyostelium discoideum)

Homologues of pro-PSMB6 [cytosol] (Rattus norvegicus)

pre3 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002789.1

Guide to Pharmacology - Targets

2407

OpenTargets

ENSG00000142507

ENSEMBL

ENSG00000142507, ENST00000270586, ENSP00000270586

IntEnz

3.4.25.1

HPA

ENSG00000142507-PSMB6

GeneCards

PSMB6

PRO

P28072

Pharos - Targets

P28072

GlyGen

P28072

PDB

5VFQ, 7W3B, 6RGQ, 7W3G, 6MSB, 7W3A, 7QXU, 9E8Q, 5VFS, 6MSJ, 6KWY, 7V5M, 6WJD, 7PG9, 9HMN, 7QYA, 6R70, 9E8G, 5LEZ, 8TM6, 5LF6, 5T0C, 5LF4, 5LEY, 5T0I, 4R67, 7NAP, 5T0H, 8YIZ, 7V5G, 8QYN, 5LE5, 7NHT, 7QY7, 7QXX, 7W3C, 8CVR, 7W3F, 5GJR, 8BZL, 5VFP, 6MSH, 6WJN, 7W37, 6MSG, 6REY, 5VFR, 7W3J, 7W3H, 5VFU, 4R3O, 7W38, 6XMJ, 5VFT, 6MSK, 8CVS, 8UD9, 8YIY, 7NAN, 7NAQ, 5A0Q, 7LXV, 8CVT, 7QYB, 5L4G, 5LF3, 5LEX, 5T0J, 5M32, 5LF1, 5LF7, 5LF0, 7NAO, 5T0G, 8QYO, 8QYS, 5LN3, 8YIX, 5VFO, 7QXN, 7QXP, 5GJQ, 6MSE, 7QXW, 7W3M, 6MSD, 7W3K, 7W3I, 7W39, 8CXB, 9E8O

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.879	12
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312)	0.804	6
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.756	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.725	7
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340)	0.643	4
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.643	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.643	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	3
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3
UniProt:P04578 env	7	Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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