Reactome | pro-PSMB4 [cytosol]

pro-PSMB4 [cytosol]

Stable Identifier

R-HSA-9908138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Precursor of proteasome subunit beta-7

Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2

Expand all

External Reference Information

External Reference

UniProt:P28070 PSMB4

Gene Names

PSMB4, PROS26

Chain

propeptide:1-45, chain:46-264

Reference Genes

BioGPS Gene:5692 PSMB4

COSMIC (genes):PSMB4 PSMB4

CTD Gene:5692 PSMB4

dbSNP Gene:5692 PSMB4

ENSEMBL:ENSG00000159377 PSMB4

ENSEMBL_homo_sapiens_GENE:ENSG00000159377.11 PSMB4

HGNC:9541 PSMB4

KEGG Gene (Homo sapiens):5692 PSMB4

Monarch:5692 PSMB4

NCBI Gene:5692 PSMB4

OMIM:602177 PSMB4

UCSC:P28070 PSMB4

Reference Transcript

RefSeq:NM_002796.2 PSMB4

Other Identifiers

11715407_s_at

11715408_x_at

11754271_a_at

1311_at

16670850

202243_PM_s_at

202243_s_at

202244_PM_at

202244_at

2358907

2358908

2358909

2358911

2358912

2358913

2358914

2358916

2358919

2358921

2358923

33154_at

5692

7905395

A_23_P761

D26600_at

GE81194

GO:0000502

GO:0001530

GO:0002376

GO:0002862

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005839

GO:0005856

GO:0005929

GO:0006954

GO:0008289

GO:0010498

GO:0019774

GO:0030163

GO:0036064

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003013847

ILMN_1737862

PH_hs_0004994

g4506198_3p_at

Participates

as an input of

as a component of

Other forms of this molecule

PSMB4(1-45) [cytosol]

PSMB4 [nucleoplasm]

PSMB4 [cytosol]

Inferred To

psmB4-1 [cytosol] (Dictyostelium discoideum)

PRE4 [cytosol] (Saccharomyces cerevisiae)

bpro-PSMB4 [cytosol] (Bos taurus)

Prosbeta7 [cytosol] (Drosophila melanogaster)

Ghost homologue of pro-PSMB4 [cytosol] (Canis familiaris)

Ghost homologue of pro-PSMB4 [cytosol] (Danio rerio)

Ghost homologue of pro-PSMB4 [cytosol] (Sus scrofa)

pro-PSMB4 [cytosol] (Gallus gallus)

pro-PSMB4 [cytosol] (Plasmodium falciparum)

pro-PSMB4 [cytosol] (Schizosaccharomyces pombe)

Psmb4 [cytosol] (Rattus norvegicus)

pbs-7 [cytosol] (Caenorhabditis elegans)

pro-Psmb4 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_002787.2

OpenTargets

ENSG00000159377

GeneCards

P28070

HPA

ENSG00000159377-PSMB4

Ensembl

ENSP00000290541, ENST00000290541, ENSG00000159377

PRO

P28070

Pharos - Targets

P28070

PDB

8QYN, 5LE5, 7NAN, 7PG9, 6MSH, 8UD9, 6RGQ, 6REY, 7W3A, 6MSG, 5LN3, 7NAP, 5T0C, 8CVT, 6WJD, 5M32, 7NAQ, 8CVS, 7W3C, 5T0G, 7W3F, 8CVR, 5GJQ, 7QYA, 5VFO, 5T0H, 7W3H, 5LEX, 7QY7, 7W3I, 5T0I, 6R70, 7QXN, 5VFR, 6MSB, 6AVO, 7W38, 6KWY, 6E5B, 5VFS, 5LF3, 7W3B, 5VFU, 7AWE, 6XMJ, 4R67, 7QXU, 5L4G, 5VFT, 8BZL, 7QXP, 7NHT, 7W3M, 5LF4, 5LF6, 6MSJ, 8QYS, 6MSK, 7QXX, 7LXV, 7NAO, 8QYO, 5LF7, 7QXW, 8CXB, 7W37, 7V5G, 6WJN, 5T0J, 5VFQ, 5GJR, 7W3G, 7B12, 5VFP, 5LEY, 5A0Q, 5LF0, 4R3O, 7W3J, 5LF1, 6MSE, 7QYB, 7V5M, 7W39, 6MSD, 7W3K, 5LEZ

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.862	12
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.8	9
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.788	8
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.725	5
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.725	5
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) SMAD1 [cytosol] (R-HSA-201468) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.666	4
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.666	5
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.659	4
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.659	4
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.659	4
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.643	4
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.643	5
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.643	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.643	4
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.638	3
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q8TDC0 MYOZ3			0.556	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.556	3
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q96M29 TEKT5			0.556	3
UniProt:Q99697-2 PITX2			0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q13148 TADBP			0.556	3
UniProt:Q5JUK2 SOLH1			0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:O75360 PROP1			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q9H987-2 SYNPO2L			0.556	3
UniProt:P28676 GCA	2	GCA [extracellular region] (R-HSA-6806174) GCA [azurophil granule lumen] (R-HSA-6799167)	0.556	3
UniProt:Q9Y5R4 HEMK1			0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.527	4
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	3
UniProt:P25789 PSMA4	2	PSMA4 [nucleoplasm] (R-HSA-174324) PSMA4 [cytosol] (R-HSA-68730)	0.527	3
UniProt:P28072 PSMB6	4	PSMB6(1-34) [cytosol] (R-HSA-9908141) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6 [nucleoplasm] (R-HSA-174342) PSMB6 [cytosol] (R-HSA-68756)	0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.527	4
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.527	2

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