Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DAG1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-9913254
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
fullName evidence="45"Dystroglycan 1, DAG1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
Autoproteolysis of DAG1 to alpha and beta chains (Homo sapiens)
DAG1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14118 DAG1
Gene Names
DAG1
Chain
signal peptide:1-29, chain:30-653, chain:654-895
Reference Genes
BioGPS Gene:1605 DAG1
COSMIC (genes):DAG1 DAG1
CTD Gene:1605 DAG1
dbSNP Gene:1605 DAG1
ENSEMBL:ENSG00000173402 DAG1
HGNC:2666 DAG1
KEGG:hsa:1605 DAG1
Monarch:1605 DAG1
NCBI Gene:1605 DAG1
OMIM:128239 DAG1
UCSC:Q14118 DAG1
Reference Transcript
RefSeq:NM_001177634.3 DAG1
RefSeq:XM_047447557.1 DAG1
RefSeq:NM_004393.6 DAG1
RefSeq:XM_047447551.1 DAG1
RefSeq:XM_047447565.1 DAG1
RefSeq:NM_001177635.3 DAG1
RefSeq:XM_047447561.1 DAG1
RefSeq:XM_047447548.1 DAG1
RefSeq:NM_001177642.3 DAG1
RefSeq:XM_047447578.1 DAG1
RefSeq:XM_047447553.1 DAG1
RefSeq:XM_047447569.1 DAG1
RefSeq:XM_047447570.1 DAG1
RefSeq:XM_047447572.1 DAG1
RefSeq:XM_047447567.1 DAG1
RefSeq:NM_001177644.3 DAG1
RefSeq:XM_047447544.1 DAG1
RefSeq:NM_001177640.3 DAG1
RefSeq:NM_001177637.3 DAG1
RefSeq:XM_047447563.1 DAG1
RefSeq:XM_047447576.1 DAG1
RefSeq:XM_047447546.1 DAG1
RefSeq:XM_047447574.1 DAG1
RefSeq:NM_001177639.3 DAG1
RefSeq:XM_047447542.1 DAG1
RefSeq:XM_047447540.1 DAG1
RefSeq:XM_047447555.1 DAG1
RefSeq:XM_047447559.1 DAG1
RefSeq:NM_001177638.3 DAG1
RefSeq:XM_047447575.1 DAG1
RefSeq:NM_001165928.4 DAG1
RefSeq:XM_047447560.1 DAG1
RefSeq:XM_047447579.1 DAG1
RefSeq:NM_001177641.3 DAG1
RefSeq:XM_047447545.1 DAG1
RefSeq:XM_047447558.1 DAG1
RefSeq:XM_047447562.1 DAG1
RefSeq:XM_047447556.1 DAG1
RefSeq:XM_047447564.1 DAG1
RefSeq:XM_047447566.1 DAG1
RefSeq:XM_047447549.1 DAG1
RefSeq:XM_047447568.1 DAG1
RefSeq:XM_047447573.1 DAG1
RefSeq:NM_001177636.3 DAG1
RefSeq:XM_047447543.1 DAG1
RefSeq:XM_047447541.1 DAG1
RefSeq:NM_001177643.3 DAG1
RefSeq:XM_047447552.1 DAG1
RefSeq:XM_047447550.1 DAG1
RefSeq:XM_047447571.1 DAG1
RefSeq:XM_047447547.1 DAG1
RefSeq:XM_047447554.1 DAG1
RefSeq:XM_047447539.1 DAG1
RefSeq:XM_047447577.1 DAG1
Participates
as an input of
Autoproteolysis of DAG1 to alpha and beta chains (Homo sapiens)
Other forms of this molecule
DAG1(654-895) [plasma membrane]
DAG1(30-653) [extracellular region]
DAG1(30-653) [cytosol]
DAG1(30-653) [endoplasmic reticulum lumen]
Man-DAG1 [endoplasmic reticulum lumen]
DAG1(654-895) [endoplasmic reticulum membrane]
Core M1,3-DAG1 [Golgi lumen]
Core M1,2,3-DAG1 [Golgi lumen]
Core M3-DAG1 [Golgi lumen]
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
Matriglycan-DAG1 [Golgi lumen]
3S-Matriglycan-DAG1 [Golgi lumen]
Man-DAG1 [Golgi lumen]
GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region]
DAG1(654-895) [Golgi membrane]
Inferred To
dag1 [endoplasmic reticulum membrane]
(Danio rerio)
dag1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
dgn-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Dg [endoplasmic reticulum membrane]
(Drosophila melanogaster)
DAG1 [endoplasmic reticulum membrane]
(Bos taurus)
DAG1 [endoplasmic reticulum membrane]
(Canis familiaris)
DAG1 [endoplasmic reticulum membrane]
(Gallus gallus)
DAG1 [endoplasmic reticulum membrane]
(Sus scrofa)
Dag1 [endoplasmic reticulum membrane]
(Mus musculus)
Dag1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_047303514.1
,
NP_001171114.2
,
XP_047303516.1
,
NP_001171108.2
,
NP_001171112.2
,
XP_047303534.1
,
XP_047303495.1
,
NP_001171106.2
,
XP_047303508.1
,
XP_047303506.1
,
NP_001159400.3
,
XP_047303529.1
,
XP_047303523.1
,
XP_047303532.1
,
XP_047303522.1
,
XP_047303519.1
,
NP_001171111.2
,
XP_047303515.1
,
XP_047303510.1
,
XP_047303526.1
,
NP_001171105.2
,
XP_047303512.1
,
NP_001171109.2
,
XP_047303505.1
,
XP_047303503.1
,
XP_047303524.1
,
NP_001171107.2
,
XP_047303498.1
,
XP_047303535.1
,
XP_047303521.1
,
XP_047303518.1
,
XP_047303525.1
,
XP_047303502.1
,
XP_047303504.1
,
XP_047303527.1
,
NP_001171110.2
,
XP_047303497.1
,
NP_001171113.2
,
XP_047303500.1
,
XP_047303499.1
,
XP_047303511.1
,
XP_047303530.1
,
XP_047303520.1
,
NP_001171115.2
,
XP_047303501.1
,
XP_047303517.1
,
XP_047303513.1
,
XP_047303531.1
,
XP_047303507.1
,
XP_047303509.1
,
XP_047303533.1
,
NP_004384.5
,
XP_047303496.1
,
XP_047303528.1
OpenTargets
ENSG00000173402
ENSEMBL
ENST00000418588
,
ENST00000452317
,
ENSP00000401805
,
ENST00000469139
,
ENST00000308775
,
ENST00000673708
,
ENSP00000410145
,
ENST00000496474
,
ENSP00000312435
,
ENST00000435508
,
ENST00000431960
,
ENST00000430636
,
ENSP00000401382
,
ENST00000466701
,
ENSP00000412067
,
ENST00000428779
,
ENST00000697271
,
ENSP00000415321
,
ENSP00000388833
,
ENSP00000405859
,
ENSG00000173402
,
ENSP00000501140
,
ENSP00000513216
,
ENSP00000501165
,
ENSP00000513217
,
ENSP00000513218
,
ENST00000452060
,
ENSP00000387859
,
ENST00000421560
GeneCards
DAG1
HPA
ENSG00000173402-DAG1
PRO
Q14118
Pharos - Targets
Q14118
GlyGen
Q14118
Orphanet
DAG1
PDB
2MK7
,
6JJY
,
7E9L
,
7E9K
,
5GGP
,
1EG4
,
5LLK
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14118 DAG1
20
DAG1(654-895) [plasma membrane]
(R-HSA-2328154)
DAG1(30-653) [extracellular region]
(R-HSA-2328152)
DAG1(30-653) [cytosol]
(R-HSA-5615641)
DAG1(30-653) [endoplasmic reticulum lumen]
(R-HSA-8931890)
Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-5615647)
DAG1 [endoplasmic reticulum membrane]
(R-HSA-9913254)
DAG1(654-895) [endoplasmic reticulum membrane]
(R-HSA-9913257)
Core M1,3-DAG1 [Golgi lumen]
(R-HSA-5617087)
Core M1,2,3-DAG1 [Golgi lumen]
(R-HSA-8932424)
Core M3-DAG1 [Golgi lumen]
(R-HSA-9940750)
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931659)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931656)
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931673)
RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940668)
Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940723)
RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940763)
GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940727)
Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]
(R-HSA-9940697)
Matriglycan-DAG1 [Golgi lumen]
(R-HSA-9940706)
3S-Matriglycan-DAG1 [Golgi lumen]
(R-HSA-9940731)
0.558
2
UniProt:P46939 UTRN
1
UTRN [cytosol]
(R-HSA-5216039)
0.527
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:O00214 LEG8
0.527
2
UniProt:Q9NU53 GINM1
0.527
2
UniProt:Q9Y5G4 PCDG9
0.527
2
UniProt:Q8WXA8 HTR3C
1
HTR3C [plasma membrane]
(R-HSA-975312)
0.527
2
UniProt:O95302 FKBP9
1
FKBP9 [cytosol]
(R-HSA-391306)
0.527
2
UniProt:Q9Y5F2 PCDBB
0.527
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.527
2
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.527
2
UniProt:P20036 HLA-DPA1
9
HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]
(R-HSA-197586)
HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]
(R-HSA-2130639)
HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130435)
HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130485)
HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]
(R-HSA-2130648)
HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130337)
HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]
(R-HSA-2214387)
HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130739)
HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130667)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.527
2
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text