Reactome | MYB [nucleoplasm]

MYB [nucleoplasm]

Stable Identifier

R-HSA-992697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional activator Myb, MYB_HUMAN, c-Myb

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
        
        MYB [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB [nucleoplasm] (Homo sapiens)
        
        RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10242 MYB

Gene Names

MYB

Chain

chain:1-640

Reference Genes

BioGPS Gene:4602 MYB

COSMIC (genes):MYB MYB

CTD Gene:4602 MYB

dbSNP Gene:4602 MYB

ENSEMBL:ENSG00000118513 MYB

HGNC:7545 MYB

KEGG:hsa:4602 MYB

Monarch:4602 MYB

NCBI Gene:4602 MYB

OMIM:189990 MYB

UCSC:P10242 MYB

Reference Transcript

Other Identifiers

11727722_a_at

11730483_a_at

1471_at

1472_g_at

1473_s_at

1474_s_at

1475_s_at

1476_s_at

17012804

2042_s_at

204798_PM_at

204798_at

215152_PM_at

215152_at

2926803

2926804

2926808

2926809

2926810

2926811

2926813

2926814

2926816

2926817

2926819

2926820

2926821

2926822

2926823

2926824

2926825

2926826

2926827

2926828

2926829

2926830

2926831

2926836

2926837

41854_at

4602

8122202

A_14_P103547

A_14_P105105

A_23_P31073

A_33_P3311795

GE59013

GO:0000122

GO:0000278

GO:0000978

GO:0000981

GO:0001228

GO:0001666

GO:0002376

GO:0002931

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0006357

GO:0010468

GO:0014856

GO:0016020

GO:0016363

GO:0030154

GO:0030218

GO:0032967

GO:0043226

GO:0043525

GO:0045064

GO:0045653

GO:0045892

GO:0045893

GO:0045944

GO:0048661

GO:0048856

GO:0060252

GO:0061515

GO:0070301

GO:0071300

GO:0071636

GO:0090575

GO:0140110

GO:1901533

GO:1902895

GO:1904899

GO:2000491

GO:2000845

HMNXSV003004410

HMNXSV003017603

HMNXSV003028647

Hs.1334.1.S1_3p_at

ILMN_1711894

M13666_at

PH_hs_0024709

TC06001010.hg

TC06003069.hg

TC06003070.hg

U22376_cds2_s_at

g4885496_3p_at

Participates

as an output of

as a component of

as an input of

Cross References

OpenTargets

ENSG00000118513

ENSEMBL

ENSP00000434723, ENST00000442647, ENST00000533837, ENST00000367812, ENST00000525514, ENSP00000435578, ENSP00000339992, ENSP00000435055, ENSP00000437081, ENSP00000356788, ENSP00000356786, ENST00000533384, ENSP00000435938, ENSP00000436605, ENST00000525369, ENST00000367814, ENSP00000410825, ENSP00000434639, ENST00000341911, ENST00000528774, ENSP00000437264, ENST00000529586, ENST00000534044, ENST00000534121, ENSP00000432851, ENSP00000432811, ENST00000525477, ENSP00000435293, ENST00000533808, ENST00000533624

HPA

ENSG00000118513-MYB

PRO

P10242

Pharos - Targets

P10242

Orphanet

MYB

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H074-2 PAIP1			0.556	3
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.544	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.544	3
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.536	2
UniProt:Q5TKA1 LIN9	1	LIN9 [nucleoplasm] (R-HSA-389108)	0.536	2
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.536	2
UniProt:O15083 ERC2			0.524	2
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [plasma membrane] (R-HSA-2980668)	0.499	4

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