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MFN2 [mitochondrial outer membrane]
Stable Identifier
R-HSA-992714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-2, MFN2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)
Mitofusin complex [mitochondrial outer membrane] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Miro GTPase Cycle (Homo sapiens)
RHOT2 GTPase cycle (Homo sapiens)
RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)
RHOT2 effectors [cytosol] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
RHOT2:GTP:RHOT2 effectors [mitochondrial outer membrane] (Homo sapiens)
RHOT2 effectors [cytosol] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95140 MFN2
Gene Names
MFN2, CPRP1, KIAA0214
Chain
chain:1-757
Reference Genes
BioGPS Gene:9927 MFN2
COSMIC (genes):MFN2 MFN2
CTD Gene:9927 MFN2
dbSNP Gene:9927 MFN2
ENSEMBL:ENSG00000116688 MFN2
HGNC:16877 MFN2
KEGG:hsa:9927 MFN2
Monarch:9927 MFN2
NCBI Gene:9927 MFN2
OMIM:608507 MFN2
UCSC:O95140 MFN2
Reference Transcript
RefSeq:XM_005263548.3 MFN2
RefSeq:XM_005263545.3 MFN2
RefSeq:NM_014874.3 MFN2
RefSeq:XM_005263543.3 MFN2
RefSeq:XM_005263547.3 MFN2
RefSeq:NM_001127660.1 MFN2
Other Identifiers
11739020_a_at
11741010_a_at
11748427_a_at
16659171
201155_PM_s_at
201155_s_at
216205_PM_s_at
216205_s_at
2320620
2320622
2320623
2320624
2320625
2320626
2320628
2320629
2320630
2320631
2320632
2320633
2320635
2320636
2320637
2320638
2320639
2320641
2320642
2320643
2320644
2320645
2320646
2320647
2320648
2320649
2320650
2320651
2320652
2320653
2320654
2320655
2320656
34369_at
68083_at
7897824
9927
A_14_P132643
A_23_P126135
A_33_P3320277
GE57383
GO:0001825
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0006091
GO:0006626
GO:0006914
GO:0006915
GO:0006986
GO:0007005
GO:0007006
GO:0008053
GO:0009060
GO:0012501
GO:0015630
GO:0016020
GO:0016787
GO:0031625
GO:0034497
GO:0043226
GO:0046580
GO:0048593
GO:0048662
GO:0051646
GO:0061024
GO:0061734
GO:0120162
GO:1904707
GO:1905461
HMNXSV003052093
Hs.3363.2.S1_3p_a_at
ILMN_1651385
PH_hs_0024267
TC01000152.hg
g7662003_3p_a_at
Participates
as a member of
RHOT2 effectors [cytosol] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
p-S65-Ub:MFN2 [mitochondrial outer membrane]
K63polyUb-MFN2 [mitochondrial outer membrane]
K48polyUb-MFN2 [mitochondrial outer membrane]
Ub-MFN2 [mitochondrial outer membrane]
Inferred To
Homologues of MFN2 [mitochondrial outer membrane]
(Drosophila melanogaster)
MFN2 [mitochondrial outer membrane]
(Bos taurus)
MFN2 [mitochondrial outer membrane]
(Caenorhabditis elegans)
MFN2 [mitochondrial outer membrane]
(Canis familiaris)
MFN2 [mitochondrial outer membrane]
(Drosophila melanogaster)
MFN2 [mitochondrial outer membrane]
(Gallus gallus)
MFN2 [mitochondrial outer membrane]
(Mus musculus)
MFN2 [mitochondrial outer membrane]
(Plasmodium falciparum)
MFN2 [mitochondrial outer membrane]
(Rattus norvegicus)
MFN2 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
MFN2 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
MFN2 [mitochondrial outer membrane]
(Sus scrofa)
mfn2 [mitochondrial outer membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001121132.1
,
NP_055689.1
,
XP_005263602.1
,
XP_005263605.1
,
XP_005263604.1
,
XP_005263600.1
Guide to Pharmacology - Targets
3131
OpenTargets
ENSG00000116688
ENSEMBL
ENSP00000235329
,
ENSP00000502404
,
ENSP00000502623
,
ENSP00000501776
,
ENSP00000501716
,
ENSP00000501646
,
ENST00000675053
,
ENST00000675231
,
ENST00000676293
,
ENST00000235329
,
ENST00000675113
,
ENSP00000502185
,
ENSP00000502151
,
ENSP00000502362
,
ENST00000444836
,
ENST00000674910
,
ENST00000674817
,
ENSP00000416338
,
ENST00000674548
,
ENST00000675919
HPA
ENSG00000116688-MFN2
PRO
O95140
Pharos - Targets
O95140
Orphanet
MFN2
HMDB Protein
HMDBP08482
PDB
6JFK
,
6JFL
,
6JFM
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.576
4
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
3
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