Reactome | CSN5 [cytosol]

CSN5 [cytosol]

Stable Identifier

R-HSA-9929354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        GSK3B-mediated proteasomal degradation of PD-L1(CD274) (Homo sapiens)
        
        Deubiquitination of CD274 (Homo sapiens)
        
        CSN5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92905 COPS5

Gene Names

COPS5, CSN5, JAB1

Chain

initiator methionine:1, chain:2-334

Reference Genes

BioGPS Gene:10987 COPS5

COSMIC (genes):COPS5 COPS5

CTD Gene:10987 COPS5

dbSNP Gene:10987 COPS5

ENSEMBL:ENSG00000121022 COPS5

HGNC:2240 COPS5

KEGG:hsa:10987 COPS5

Monarch:10987 COPS5

NCBI Gene:10987 COPS5

OMIM:604850 COPS5

UCSC:Q92905 COPS5

Reference Transcript

RefSeq:NM_006837.2 COPS5

Other Identifiers

10987

11721461_a_at

11754844_x_at

17077888

1789_at

201652_PM_at

201652_at

3138979

3138980

3138981

3138982

3138983

3138984

3138985

3138987

3138990

3138992

3138993

3138994

3138995

3138996

3138997

3138998

3138999

3139000

3139001

3139002

3139003

3139004

3139005

3139006

3139007

3139008

3139009

3139012

3139014

8151136

A_23_P71419

GE62793

GO:0000338

GO:0000785

GO:0003713

GO:0003743

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005852

GO:0006355

GO:0006412

GO:0006413

GO:0006508

GO:0008021

GO:0008180

GO:0008233

GO:0008237

GO:0016192

GO:0016787

GO:0019784

GO:0019899

GO:0031410

GO:0035718

GO:0043066

GO:0043687

GO:0045116

GO:0045202

GO:0045944

GO:0046328

GO:0046872

GO:0048471

GO:0051091

GO:0051726

GO:0140492

GO:1903894

GO:1990182

GO:2000434

HMNXSV003027773

ILMN_1736002

PH_hs_0030317

U65928_at

g5803045_3p_at

Other forms of this molecule

COPS5 [nucleoplasm]

COPS5 [cytosol]

Inferred To

COPS5 [cytosol] (Bos taurus)

COPS5 [cytosol] (Canis familiaris)

COPS5 [cytosol] (Gallus gallus)

Cops5 [cytosol] (Mus musculus)

Cops5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006828.2

OpenTargets

ENSG00000121022

ENSEMBL

ENSP00000350512, ENSG00000121022, ENST00000357849

GeneCards

COPS5

HPA

ENSG00000121022-COPS5

PRO

Q92905

Pharos - Targets

Q92905

GlyGen

Q92905

PDB

6R7H, 6R7I, 8H3A, 8H3F, 4D10, 8H38, 6R7F, 6R6H, 5JOH, 5M5Q, 4F7O, 4D18, 5JOG, 4WSN

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13098 GPS1	2	GPS1 [nucleoplasm] (R-HSA-5697010) GPS1 [cytosol] (R-HSA-416972)	0.942	20
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.932	20
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.927	28
UniProt:Q99627 COPS8	2	COPS8 [cytosol] (R-HSA-416962) COPS8 [nucleoplasm] (R-HSA-5697014)	0.915	15
UniProt:P61201 COPS2	2	COPS2 [nucleoplasm] (R-HSA-5697012) COPS2 [cytosol] (R-HSA-416971)	0.915	13
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.894	12
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.894	12
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.892	12
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.892	17
UniProt:Q92466 DDB2	3	PAR-DDB2 [nucleoplasm] (R-HSA-5696654) DDB2 [nucleoplasm] (R-HSA-53491) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.877	11
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.837	14
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.823	13
UniProt:Q9BX70 BTBD2			0.788	9
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.788	9
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.783	15
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.736	9
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.725	4
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.725	7
UniProt:Q9Y4B6 DCAF1	1	VPRBP [cytosol] (R-HSA-975984)	0.725	7
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.725	11
UniProt:Q8WV16 DCAF4	1	DCAF4 [nucleoplasm] (R-HSA-8955191)	0.725	6
UniProt:Q96M94 KLH15			0.643	4
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.643	4
UniProt:Q6JEL2 KLH10			0.643	5
UniProt:Q9C0C6 CIPC	1	CIPC [nucleoplasm] (R-HSA-9911267)	0.643	3
UniProt:Q15048 LRRC14	1	LRRC14 [cytosol] (R-HSA-9749455)	0.643	4
UniProt:Q96L50 LRR1	1	LRR1 [cytosol] (R-HSA-976019)	0.643	6
UniProt:Q8TEB1 DCAF11	1	DCAF11 [nucleoplasm] (R-HSA-8863251)	0.643	5
UniProt:Q13216 ERCC8	1	ERCC8 [nucleoplasm] (R-HSA-52835)	0.643	6
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.643	6
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.639	10
UniProt:Q8IWQ3 BRSK2			0.639	6
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.639	8
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.602	3
UniProt:P55789 GFER	1	GFER [mitochondrial intermembrane space] (R-HSA-1252051)	0.599	4
UniProt:P14174 MIF	3	MIF [extracellular region] (R-HSA-212594) MIF [secretory granule lumen] (R-HSA-6803282) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.593	3
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.593	4
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	5
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.553	2
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.547	2
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.547	2
UniProt:Q9NSI6 BRWD1	1	BRWD1 [nucleoplasm] (R-HSA-8863306)	0.547	2
UniProt:Q9H8M7 MINY3			0.543	3
UniProt:O95273 CCDB1			0.543	5
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.543	3
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.528	2
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.527	2
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.527	3
UniProt:Q5VUJ6 LRCH2			0.527	2
UniProt:O95704 APBB3			0.527	3
UniProt:Q6PJ61 FBX46			0.527	2
UniProt:Q7L5Y6 DET1	1	DET1 [cytosol] (R-HSA-976007)	0.527	3
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [secretory granule lumen] (R-HSA-6801472)	0.527	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.527	2
UniProt:Q9NZJ0 DTL	1	DTL [nucleoplasm] (R-HSA-975985)	0.527	4
UniProt:Q9UK73 FEM1B	1	FEM1B [cytosol] (R-HSA-201572)	0.527	2
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	2
UniProt:O94889 KLH18			0.527	5
UniProt:Q8WXC6 CSN9			0.527	3
UniProt:Q8TF40 FNIP1	1	FNIP1 [cytosol] (R-HSA-9640247)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	3
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.527	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	6
UniProt:O43583 DENR			0.527	3
UniProt:Q9H496 IFG15			0.527	5
UniProt:Q53GT1 KLHL22	1	KLHL22 [cytosol] (R-HSA-8863210)	0.527	3
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.527	2
UniProt:Q9P2N7 KLHL13	1	KLHL13 [cytosol] (R-HSA-976041)	0.527	5
UniProt:Q9P2J3 KLHL9	1	KLHL9 [cytosol] (R-HSA-976056)	0.527	3
UniProt:Q6TFL4 KLH24			0.527	2
UniProt:Q9P2K6 KLHL42	1	KLHL42 [cytosol] (R-HSA-8863204)	0.527	2
UniProt:P48741 HSPA7	2	HSPA7 [cytosol] (R-HSA-5251954) HSPA7 [nucleoplasm] (R-HSA-5252047)	0.527	2
UniProt:P11021 HSPA5	7	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [plasma membrane] (R-HSA-9922467) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.527	2
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.499	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.491	2
UniProt:O60885-3 BRD4			0.488	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.462	2

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