Reactome | CCNA:CDK1 phosphorylates MIS18BP1

CCNA:CDK1 phosphorylates MIS18BP1

Stable Identifier

R-HSA-9929904

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MIS18BP1 (also known as M18BP1 or Mis18-binding protein 1), a component of the MIS18 complex that regulates targeting of CENPA to centromeres (Fujita et al. 2007), was reproducibly identified as a CCNA:CDK1 target in a high-throughput screen (Dumitru et al. 2017). In G2, phosphorylation of a consensus CDK site T653 in MIS18BP1, which is dependent on CDK1/CDK2 activity, prevents premature recruitment of MIS18BP1 to the centromeres, while it does not affect the assembly of the MIS18 complex (Stankovic et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
28017591	A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly Garcia, BA, Shabanowitz, J, Mata, JF, Jansen, LET, Guo, LY, Black, BE, Stankovic, A, Hunt, DF, Cao, XJ, Bodor, DL, Bailey, AO	Mol Cell	2017
29154753	Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability Dumitru, AMG, Compton, DA, Kettenbach, AN, Clark, AEM, Rusin, SF	Elife	2017