Reactome | ZC3H18 [nucleoplasm]

ZC3H18 [nucleoplasm]

Stable Identifier

R-HSA-9930040

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="9"Zinc finger CCCH domain-containing protein 18, ZCH18_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P19784 CSNK2A2

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External Reference Information

External Reference

UniProt:Q86VM9 ZC3H18

Gene Names

ZC3H18, NHN1

Chain

chain:1-953

Reference Genes

BioGPS Gene:124245 ZC3H18

COSMIC (genes):ZC3H18 ZC3H18

CTD Gene:124245 ZC3H18

dbSNP Gene:124245 ZC3H18

ENSEMBL:ENSG00000158545 ZC3H18

HGNC:25091 ZC3H18

KEGG:hsa:124245 ZC3H18

Monarch:124245 ZC3H18

NCBI Gene:124245 ZC3H18

UCSC:Q86VM9 ZC3H18

Reference Transcript

Other Identifiers

11730297_a_at

11747007_a_at

11747287_a_at

11754791_x_at

124245

16821807

226108_3p_at

226108_PM_at

226108_at

238416_PM_x_at

238416_x_at

3673517

3673518

3673519

3673520

3673521

3673523

3673524

3673527

3673532

3673534

3673535

3673537

3673538

3673539

3673540

3673541

3673542

3673543

3673555

3673556

3673557

3673558

3673559

3673560

3673561

3673562

3673563

3673564

3673565

3673566

3673567

3673568

3673569

3673570

3673571

3673572

3673573

3673574

3673575

3673576

3673577

3673578

3673579

3673580

3673581

3673582

47551_at

47552_g_at

77235_at

7997779

81705_at

84060_at

A_14_P100948

A_14_P112289

A_14_P137548

A_23_P3502

A_33_P3347465

GE79034

GE88042

GO:0003723

GO:0005515

GO:0005634

GO:0008270

GO:0016607

GO:0030674

GO:0032991

GO:0046872

GO:0050779

GO:0060090

GO:0140262

GO:1990904

HMNXSV003019816

Hs.259468.0.A1_3p_at

Hs.93670.0.S1_3p_at

Hs.93670.0.S1_3p_s_at

ILMN_1658834

PH_hs_0005143

TC16000680.hg

Participates

as an output of

The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)

as an input of

The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA (Homo sapiens)

as a component of

Inferred To

Zc3h18 [nucleoplasm] (Mus musculus)

Zc3h18 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of ZC3H18 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ZC3H18 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ZC3H18 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ZC3H18 [nucleoplasm] (Schizosaccharomyces pombe)

Dmel\CG1677 [nucleoplasm] (Drosophila melanogaster)

ZC3H18 [nucleoplasm] (Bos taurus)

ZC3H18 [nucleoplasm] (Canis familiaris)

ZC3H18 [nucleoplasm] (Gallus gallus)

ZC3H18 [nucleoplasm] (Sus scrofa)

zc3h18 [nucleoplasm] (Danio rerio)

zc3h18 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001281269.1, NP_653205.3

OpenTargets

ENSG00000158545

ENSEMBL

ENST00000301011, ENSG00000158545, ENSP00000301011

GeneCards

ZC3H18

HPA

ENSG00000158545-ZC3H18

PRO

Q86VM9

Pharos - Targets

Q86VM9

GlyGen

Q86VM9

Interactors (86)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13523 PRP4K	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.788	6
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.725	9
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.725	9
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.659	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	10
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	6
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.643	10
UniProt:Q7Z6E9 RBBP6	2	RBBP6 [cytosol] (R-HSA-8850895) RBBP6 [nucleoplasm] (R-HSA-9970176)	0.643	4
UniProt:P78332 RBM6			0.643	3
UniProt:P49756 RBM25	1	RBM25 [nucleoplasm] (R-HSA-9770250)	0.643	3
UniProt:Q8NCB2 CAMKV			0.643	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.643	3
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.615	6
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.615	3
UniProt:Q13595 TRA2A			0.615	5
UniProt:Q8N3X1 FNBP4			0.527	2
UniProt:O75494 SRSF10	1	SRSF10 [nucleoplasm] (R-HSA-8866646)	0.527	6
UniProt:Q96PL5 ERMAP			0.527	3
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.527	2
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.527	5
UniProt:Q9HAZ1 CLK4			0.527	2
UniProt:Q5VTL8 PR38B			0.527	2
UniProt:Q8WXF0 SRSF12	1	SRSF12 [nucleoplasm] (R-HSA-9770127)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q9H0U9 TSYL1			0.527	2
UniProt:Q5VWQ0 RSBN1			0.527	2
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.527	2
UniProt:Q9H000 MKRN2			0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P57052 RBM11			0.527	2
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.527	3
UniProt:Q96JJ6 JPH4			0.527	2
UniProt:Q5T200 ZC3HD			0.527	2
UniProt:Q69YN4 VIR			0.527	2
UniProt:P30414 NKTR			0.527	2
UniProt:Q96E39 RMXL1			0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	2
UniProt:Q8IUX4 ABC3F			0.527	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.527	2
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	2
UniProt:Q8NDT2 RB15B			0.527	2
UniProt:Q0VGE8 ZNF816	1	ZNF816 [nucleoplasm] (R-HSA-9843461)	0.527	2
UniProt:Q9NUD5 ZCHC3			0.527	2
UniProt:Q9Y383 LC7L2			0.527	3
UniProt:Q9UL59 ZNF214	1	ZNF214 [nucleoplasm] (R-HSA-1027353)	0.527	2
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.527	2
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.527	2
UniProt:P62995 TRA2B	2	TRA2B [nucleoplasm] (R-HSA-8850859) TRA2B [cytosol] (R-HSA-9715137)	0.527	5
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	2
UniProt:Q96RR1 TWNK	1	TWNK [mitochondrial matrix] (R-HSA-1592222)	0.527	2
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.527	2
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	5
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	2
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.527	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:Q9H4G0 EPB41L1	2	EPB41L1 [cytosol] (R-HSA-392241) EPB41L1 [plasma membrane] (R-HSA-416333)	0.527	2
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.527	5
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.527	6
UniProt:Q13247 SRSF6	1	SRSF6 [nucleoplasm] (R-HSA-72026)	0.527	6
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	2
UniProt:Q9NS56 TOPORS	2	monoSUMO1-K560-TOPORS [nucleoplasm] (R-HSA-4551754) TOPORS [nucleoplasm] (R-HSA-2993791)	0.527	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:Q9H5Z1 DHX35	1	DHX35 [nucleoplasm] (R-HSA-9770427)	0.527	2
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	2
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:P49759 CLK1			0.527	2
UniProt:Q9UKM9 RALY			0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	3
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.508	2
UniProt:Q96T37 RBM15			0.483	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.483	3
UniProt:Q15233 NONO			0.483	2
UniProt:Q12906 ILF3	3	ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [nucleoplasm] (R-HSA-9760401)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.483	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	6
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.483	5

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