Reactome | Aerobactin binds Fe3+

Aerobactin binds Fe3+

Stable Identifier

R-HSA-9930941

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Escherichia coli

Compartment

extracellular region

ReviewStatus

3/5

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The main E.coli siderophore of hydroxamate/citrate type is aerobactin. It binds Fe3+ with high affinity (Brock et al., 1991; Ho et al., 2017).

Literature References

PubMed ID	Title	Journal	Year
1831796	Relative availability of transferrin-bound iron and cell-derived iron to aerobactin-producing and enterochelin-producing strains of Escherichia coli and to other microorganisms Brock, JH, Williams, PH, Licéaga, J, Wooldridge, KG	Infect Immun	1991
28771269	Utilizing an iron(iii)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria Ho, YH, Ho, SY, Hsu, CC, Shie, JJ, Wang, TA	Chem Commun (Camb)	2017

Participants

Input

Output

Participates

as an event of

Metal ion assimilation from the host (Homo sapiens)

Disease

Name	Identifier	Synonyms
bacterial infectious disease	DOID:104

Cross References

Mondo

0005113

Authored

Stephan, R (2024-12-06)

Created

Stephan, R (2024-12-07)

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