Reactome | SLC25A51 mediates mitochondrial uptake of NAD+

SLC25A51 mediates mitochondrial uptake of NAD+

Stable Identifier

R-HSA-9938195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix

Synonyms

NAD(+)(in) = NAD(+)(out)

ReviewStatus

5/5

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SLC25A51 mediates mitochondrial uptake of NAD+

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Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51, located in the inner mitochondrial membrane (Luongo et al. 2020), mediates the uptake of cytosolic NAD+ into the mitochondrial matrix (Kory et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
32906142	SLC25A51 is a mammalian mitochondrial NAD⁺ transporter Luongo, TS, Eller, JM, Lu, MJ, Niere, M, Raith, F, Perry, C, Bornstein, MR, Oliphint, P, Wang, L, McReynolds, MR, Migaud, ME, Rabinowitz, JD, Johnson, FB, Johnsson, K, Ziegler, M, Cambronne, XA, Baur, JA	Nature	2020
33087354	MCART1/SLC25A51 is required for mitochondrial NAD transport Kory, N, Uit de Bos, J, van der Rijt, S, Jankovic, N, Güra, M, Arp, N, Pena, IA, Prakash, G, Chan, SH, Kunchok, T, Lewis, CA, Sabatini, DM	Sci Adv	2020