Reactome | CBX5 [nucleoplasm]

CBX5 [nucleoplasm]

Stable Identifier

R-HSA-994093

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, CBX5_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of CBX5 with SUMO1 (Homo sapiens)
        
        CBX5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P45973 CBX5

Gene Names

CBX5, HP1A

Chain

chain:1-191

Reference Genes

BioGPS Gene:23468 CBX5

COSMIC (genes):CBX5 CBX5

CTD Gene:23468 CBX5

dbSNP Gene:23468 CBX5

ENSEMBL:ENSG00000094916 CBX5

ENSEMBL_homo_sapiens_GENE:ENSG00000094916.16 CBX5

HGNC:1555 CBX5

KEGG Gene (Homo sapiens):23468 CBX5

Monarch:23468 CBX5

NCBI Gene:23468 CBX5

OMIM:604478 CBX5

Reference Transcript

Other Identifiers

11716275_a_at

11716276_a_at

11716277_a_at

11716278_s_at

11716279_x_at

11716280_a_at

11740499_a_at

16765513

209715_PM_at

209715_at

212126_PM_at

212126_at

226085_PM_at

226085_at

231862_PM_at

231862_at

23468

234990_PM_at

234990_at

3456628

3456629

3456631

3456632

3456633

3456634

3456637

3456639

3456640

3456641

3456642

3456643

3456653

36236_at

3951974

39715_at

40731_at

44900_at

46565_at

50280_at

51739_r_at

76691_at

7963750

84069_at

84583_at

89500_at

A_23_P2355

A_24_P620621

A_24_P664995

GE57575

GE788066

GO:0000118

GO:0000122

GO:0000775

GO:0000776

GO:0000781

GO:0000792

GO:0003682

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005721

GO:0005730

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0010369

GO:0016605

GO:0017053

GO:0030674

GO:0032991

GO:0035064

GO:0035097

GO:0042393

GO:0042802

GO:0042826

GO:0043021

GO:0043226

GO:0044877

GO:0045892

GO:0060090

GO:0090734

GO:0140297

GO:1990904

HMNXSV003034222

Hs.12484.0.A1_3p_at

Hs.131798.0.S1_3p_at

Hs.131798.0.S1_3p_x_at

Hs.135287.0.A1_3p_at

Hs.306000.1.A1_3p_at

ILMN_1813028

L07515_at

PH_hs_0024494

TC12001566.hg

g184310_3p_at

Participates

as an input of

as a component of

as an output of

CBX5 gene expression is inhibited by E2F6 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K84,K-CBX5 [nucleoplasm]

Inferred To

HP1b [nucleoplasm] (Drosophila melanogaster)

chp2 [nucleoplasm] (Schizosaccharomyces pombe)

swi6 [nucleoplasm] (Schizosaccharomyces pombe)

hpl-1 [nucleoplasm] (Caenorhabditis elegans)

Cbx5 [nucleoplasm] (Mus musculus)

Cbx5 [nucleoplasm] (Rattus norvegicus)

hcpC [nucleoplasm] (Dictyostelium discoideum)

Homologues of CBX5 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CBX5 [nucleoplasm] (Schizosaccharomyces pombe)

cbx5 [nucleoplasm] (Danio rerio)

chp1 [nucleoplasm] (Schizosaccharomyces pombe)

hcpB [nucleoplasm] (Dictyostelium discoideum)

hcpA [nucleoplasm] (Dictyostelium discoideum)

CBX5 [nucleoplasm] (Bos taurus)

CBX5 [nucleoplasm] (Canis familiaris)

CBX5 [nucleoplasm] (Gallus gallus)

CBX5 [nucleoplasm] (Plasmodium falciparum)

CBX5 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_036249.1, NP_001120793.1, NP_001120794.1

OpenTargets

ENSG00000094916

GeneCards

P45973

HPA

ENSG00000094916-CBX5

Ensembl

ENSP00000449207, ENSP00000401009, ENST00000209875, ENST00000439541, ENSG00000094916, ENST00000550411, ENSP00000209875

PRO

P45973

Pharos - Targets

P45973

PDB

3I3C, 3FDT

Interactors (81)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.949	18
UniProt:Q9BWN1 PRR14			0.917	12
UniProt:Q13263 TRIM28	3	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867)	0.913	15
UniProt:Q5T3J3 LRIF1			0.874	11
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.853	11
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.837	10
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.8	6
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.798	11
UniProt:Q13111 CAF1A			0.791	8
UniProt:Q13112 CAF1B			0.788	8
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.788	6
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.788	6
UniProt:Q7Z3K3 POGZ			0.784	8
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.744	4
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.742	6
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.725	4
UniProt:Q96JM3 CHAP1			0.725	4
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	5
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.702	6
UniProt:P23497-2 SP100			0.696	7
UniProt:Q9H2P0 ADNP			0.669	3
UniProt:Q9BQF6 SENP7			0.669	4
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.669	3
UniProt:P84243 H3-3A	18	MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) H3R17me2a [nucleoplasm] (R-HSA-9822613) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) H3F3A [extracellular region] (R-HSA-977567) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.667	3
UniProt:Q96JM2 ZN462			0.643	4
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.643	3
UniProt:Q6P1K2 PMF1	1	PMF1 [cytosol] (R-HSA-375320)	0.643	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.605	4
UniProt:Q5ZUS4 Q5ZUS4			0.593	6
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.573	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.573	2
UniProt:Q16695 H3-4	3	HIST3H3 [nucleoplasm] (R-HSA-181914) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186)	0.564	2
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9UMR2 DD19B			0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q14728 MFS10			0.556	3
UniProt:O75143-2 O751432			0.556	3
UniProt:Q6N043-2 ZNF280D			0.556	3
UniProt:Q8ND82 Z280C			0.556	3
UniProt:P28838 AMPL			0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:Q9NUD9 PIGV	1	PIGV [endoplasmic reticulum membrane] (R-HSA-162739)	0.556	3
UniProt:Q969W8 ZNF566	1	ZNF566 [nucleoplasm] (R-HSA-1973878)	0.527	2
UniProt:Q6N043 Z280D			0.527	2
UniProt:A8MTY0 ZNF724	1	ZNF724P [nucleoplasm] (R-HSA-2586597)	0.527	2
UniProt:O95785 WIZ			0.527	3
UniProt:Q96CS4 ZNF689	1	ZNF689 [nucleoplasm] (R-HSA-2248889)	0.527	2
UniProt:Q9H5I1 SUV39H2	1	SUV39H2 [nucleoplasm] (R-HSA-1183231)	0.527	3
UniProt:Q5TGY3 AHDC1			0.527	2
UniProt:Q6AHZ1 Z518A			0.527	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	2
UniProt:P17098 ZNF8			0.527	2
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.527	2
UniProt:Q02386 ZNF45	1	ZNF45 [nucleoplasm] (R-HSA-974999)	0.527	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.527	2
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q7Z7G2 CPLX4			0.527	2
UniProt:Q13129 RLF			0.527	2
UniProt:Q6ZSS3 ZNF621	1	ZNF621 [nucleoplasm] (R-HSA-2127582)	0.527	2
UniProt:Q6P2D0 ZFP1	1	ZFP1 [nucleoplasm] (R-HSA-974997)	0.527	2
UniProt:Q9Y6X3 MAU2	1	MAU2 [nucleoplasm] (R-HSA-1629801)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	2
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.527	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.527	2
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.527	2
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.527	2
UniProt:Q8N9R8 SCAI	1	SCAI [nucleoplasm] (R-HSA-5666012)	0.527	2
IntAct:EBI-15634422 H3K9-2			0.499	2
UniProt:Q14191 WRN	2	monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904) WRN [nucleoplasm] (R-HSA-67387)	0.499	3
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.488	2
UniProt:Q6KC79 NIPBL	1	NIPBL [nucleoplasm] (R-HSA-2506879)	0.482	2

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