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CBX5 [nucleoplasm]
Stable Identifier
R-HSA-994093
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, CBX5_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13112 CAF1B
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
CBX5 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX5 gene expression is inhibited by E2F6 (Homo sapiens)
CBX5 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)
CBX5 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
SUMOylation of CBX5 with SUMO1 (Homo sapiens)
CBX5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45973 CBX5
Gene Names
CBX5, HP1A
Chain
chain:1-191
Reference Genes
BioGPS Gene:23468 CBX5
COSMIC (genes):CBX5 CBX5
CTD Gene:23468 CBX5
dbSNP Gene:23468 CBX5
ENSEMBL:ENSG00000094916 CBX5
HGNC:1555 CBX5
KEGG:hsa:23468 CBX5
Monarch:23468 CBX5
NCBI Gene:23468 CBX5
OMIM:604478 CBX5
UCSC:P45973 CBX5
Reference Transcript
RefSeq:NM_001127322.1 CBX5
RefSeq:NM_001127321.1 CBX5
RefSeq:NM_012117.2 CBX5
Other Identifiers
11716275_a_at
11716276_a_at
11716277_a_at
11716278_s_at
11716279_x_at
11716280_a_at
11740499_a_at
16765513
209715_PM_at
209715_at
212126_PM_at
212126_at
226085_PM_at
226085_at
230752_PM_at
230752_at
231862_PM_at
231862_at
23468
234990_PM_at
234990_at
241875_PM_at
241875_at
242069_PM_at
242069_at
3456628
3456629
3456631
3456632
3456633
3456634
3456637
3456639
3456640
3456641
3456642
3456643
3456646
3456647
3456648
3456649
3456653
36236_at
3951974
39715_at
40731_at
44900_at
46565_at
50280_at
51739_r_at
55507_at
62270_at
76691_at
7963750
84069_at
84583_at
89500_at
A_23_P2355
A_24_P620621
A_24_P664995
GE57575
GE677331
GE788066
GO:0000118
GO:0000122
GO:0000775
GO:0000776
GO:0000781
GO:0000792
GO:0003682
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005721
GO:0005730
GO:0006325
GO:0006355
GO:0006974
GO:0010369
GO:0016605
GO:0017053
GO:0030674
GO:0031507
GO:0032991
GO:0035064
GO:0035097
GO:0042393
GO:0042802
GO:0042826
GO:0043021
GO:0043226
GO:0043229
GO:0044877
GO:0045892
GO:0060090
GO:0090734
GO:0140297
GO:1990904
HMNXSV003034222
Hs.12484.0.A1_3p_at
Hs.131798.0.S1_3p_at
Hs.131798.0.S1_3p_x_at
Hs.135287.0.A1_3p_at
Hs.165249.0.A1_3p_at
Hs.165249.1.S1_3p_at
Hs.306000.1.A1_3p_at
Hs.97103.0.A1_3p_at
ILMN_1813028
L07515_at
PH_hs_0024494
TC12001566.hg
g184310_3p_at
Participates
as an input of
SUMOylation of CBX5 with SUMO1 (Homo sapiens)
HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)
CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
as a component of
HP1alpha:Histone H3 methylated at K9 [nucleoplasm] (Homo sapiens)
CBX5:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement [nucleoplasm] (Homo sapiens)
as an output of
CBX5 gene expression is inhibited by E2F6 (Homo sapiens)
Other forms of this molecule
monoSUMO1-K84,K-CBX5 [nucleoplasm]
Inferred To
HP1b [nucleoplasm]
(Drosophila melanogaster)
chp2 [nucleoplasm]
(Schizosaccharomyces pombe)
swi6 [nucleoplasm]
(Schizosaccharomyces pombe)
hpl-1 [nucleoplasm]
(Caenorhabditis elegans)
Cbx5 [nucleoplasm]
(Mus musculus)
Cbx5 [nucleoplasm]
(Rattus norvegicus)
hcpC [nucleoplasm]
(Dictyostelium discoideum)
Homologues of CBX5 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of CBX5 [nucleoplasm]
(Schizosaccharomyces pombe)
cbx5 [nucleoplasm]
(Danio rerio)
chp1 [nucleoplasm]
(Schizosaccharomyces pombe)
hcpB [nucleoplasm]
(Dictyostelium discoideum)
hcpA [nucleoplasm]
(Dictyostelium discoideum)
CBX5 [nucleoplasm]
(Bos taurus)
CBX5 [nucleoplasm]
(Canis familiaris)
CBX5 [nucleoplasm]
(Gallus gallus)
CBX5 [nucleoplasm]
(Plasmodium falciparum)
CBX5 [nucleoplasm]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000094916
ENSEMBL
ENSP00000449207
,
ENST00000550411
,
ENSP00000209875
,
ENSP00000401009
,
ENST00000209875
,
ENST00000439541
HPA
ENSG00000094916-CBX5
PRO
P45973
Pharos - Targets
P45973
GlyGen
P45973
PDB
3FDT
,
3I3C
Interactors (81)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.949
18
UniProt:Q9BWN1 PRR14
0.917
12
UniProt:Q13263 TRIM28
3
TRIM28 [nucleoplasm]
(R-HSA-974998)
SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]
(R-HSA-9842867)
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
(R-HSA-3782600)
0.913
15
UniProt:Q5T3J3 LRIF1
0.874
11
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.853
11
UniProt:Q9H410 DSN1
3
DSN1 [cytosol]
(R-HSA-375308)
DSN1 [azurophil granule lumen]
(R-HSA-6799218)
DSN1 [extracellular region]
(R-HSA-6806228)
0.837
10
UniProt:Q96IY1 NSL1
1
NSL1 [cytosol]
(R-HSA-375309)
0.8
6
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.798
11
UniProt:Q13111 CAF1A
0.791
8
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.788
6
UniProt:Q13112 CAF1B
0.788
8
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.788
6
UniProt:Q7Z3K3 POGZ
0.784
8
UniProt:Q5FBB7 SGO1
1
SGOL1 [cytosol]
(R-HSA-376227)
0.744
4
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.742
6
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
5
UniProt:Q96JM3 CHAP1
0.725
4
UniProt:Q96H86 ZNF764
1
ZNF764 [nucleoplasm]
(R-HSA-3343766)
0.725
4
UniProt:Q9UIS9 MBD1
2
MBD1 [nucleoplasm]
(R-HSA-417134)
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
0.702
6
UniProt:P23497-2 SP100
0.696
7
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.669
3
UniProt:Q9BQF6 SENP7
0.669
4
UniProt:Q9H2P0 ADNP
0.669
3
UniProt:P84243 H3-3A
18
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
H3F3A [extracellular region]
(R-HSA-977567)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
Me1K5-H3-3A [nucleoplasm]
(R-HSA-9864864)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
0.667
3
UniProt:Q6P1K2 PMF1
1
PMF1 [cytosol]
(R-HSA-375320)
0.643
3
UniProt:Q9H081 MIS12
1
MIS12 [cytosol]
(R-HSA-375313)
0.643
3
UniProt:Q96JM2 ZN462
0.643
4
UniProt:Q14739 LBR
4
LBR [nuclear envelope]
(R-HSA-194637)
p-S71,S86-LBR [nuclear envelope]
(R-HSA-9624811)
LBR [endoplasmic reticulum membrane]
(R-HSA-9714334)
LBR [endosome membrane]
(R-HSA-9715094)
0.605
4
UniProt:Q5ZUS4 Q5ZUS4
0.593
6
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.573
2
UniProt:Q9BZ95 NSD3
1
WHSC1L1 [nucleoplasm]
(R-HSA-1183230)
0.573
2
UniProt:Q16695 H3-4
3
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
HIST3H3 [nucleoplasm]
(R-HSA-181914)
0.564
2
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:Q8NCS7 SLC44A5
1
SLC44A5 [plasma membrane]
(R-HSA-444459)
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9UMR2 DD19B
0.556
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.556
3
UniProt:Q9BZ95-3 Q9BZ953
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:Q14728 MFS10
0.556
3
UniProt:O75143-2 O751432
0.556
3
UniProt:Q6N043-2 ZNF280D
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
3
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.556
3
UniProt:Q9NUD9 PIGV
1
PIGV [endoplasmic reticulum membrane]
(R-HSA-162739)
0.556
3
UniProt:Q8N448 LNX2
0.556
3
UniProt:P28838 AMPL
0.556
3
UniProt:Q8ND82 Z280C
0.556
3
UniProt:Q969W8 ZNF566
1
ZNF566 [nucleoplasm]
(R-HSA-1973878)
0.527
2
UniProt:Q6N043 Z280D
0.527
2
UniProt:A8MTY0 ZNF724
1
ZNF724P [nucleoplasm]
(R-HSA-2586597)
0.527
2
UniProt:O95785 WIZ
0.527
3
UniProt:Q96CS4 ZNF689
1
ZNF689 [nucleoplasm]
(R-HSA-2248889)
0.527
2
UniProt:Q9H5I1 SUV39H2
1
SUV39H2 [nucleoplasm]
(R-HSA-1183231)
0.527
3
UniProt:Q5TGY3 AHDC1
0.527
2
UniProt:Q6AHZ1 Z518A
0.527
2
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.527
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
2
UniProt:P17098 ZNF8
0.527
2
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.527
2
UniProt:Q02386 ZNF45
1
ZNF45 [nucleoplasm]
(R-HSA-974999)
0.527
2
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.527
2
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.527
2
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.527
2
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.527
2
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.527
2
UniProt:Q7Z7G2 CPLX4
0.527
2
UniProt:Q13129 RLF
0.527
2
UniProt:Q6ZSS3 ZNF621
1
ZNF621 [nucleoplasm]
(R-HSA-2127582)
0.527
2
UniProt:Q6P2D0 ZFP1
1
ZFP1 [nucleoplasm]
(R-HSA-974997)
0.527
2
UniProt:Q9Y6X3 MAU2
1
MAU2 [nucleoplasm]
(R-HSA-1629801)
0.527
2
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.527
2
UniProt:Q8N9R8 SCAI
1
SCAI [nucleoplasm]
(R-HSA-5666012)
0.527
2
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.527
2
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.499
3
IntAct:EBI-15634422 H3K9-2
0.499
2
UniProt:Q92560 BAP1
1
BAP1 [nucleoplasm]
(R-HSA-5689665)
0.488
2
UniProt:Q6KC79 NIPBL
1
NIPBL [nucleoplasm]
(R-HSA-2506879)
0.482
2
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