F-actin capping protein binds to the barbed end of elongating F-actin

Stable Identifier
R-HSA-994169
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
F-actin capping protein binds to the barbed end of elongating F-actin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Actin capping protein (CP) was named for its ability to bind the barbed ends of actin filaments. CP inhibits the addition and loss of actin subunits at the barbed end and is important for the dynamics of actin filament assembly, and therefore important for the control of cell shape and movement. CP was called beta-actinin when first characterized and purified from muscle (Maruyama 1966). Actin polymerization is controlled by a large cellular excess of capping proteins which bind to the barbed end of actin filaments preventing elongation.
Participants
Input
Output
Participates
as an event of
Inferred From
F-actin capping protein binds to elongating F-actin (Gallus gallus)
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-05)
Cite Us!