Reactome | K63polyUb-K8-RPS20 [cytosol]

K63polyUb-K8-RPS20 [cytosol]

Stable Identifier

R-HSA-9948312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="10"Small ribosomal subunit protein uS10, RS20_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60866 RPS20

Gene Names

RPS20

Chain

initiator methionine:1, chain:2-119

Reference Genes

BioGPS Gene:6224 RPS20

COSMIC (genes):RPS20 RPS20

CTD Gene:6224 RPS20

dbSNP Gene:6224 RPS20

ENSEMBL:ENSG00000008988 RPS20

HGNC:10405 RPS20

KEGG:hsa:6224 RPS20

Monarch:6224 RPS20

NCBI Gene:6224 RPS20

OMIM:603682 RPS20

UCSC:P60866 RPS20

Reference Transcript

Other Identifiers

11737810_at

11746444_at

11757408_x_at

1560021_PM_at

1560021_at

1560023_PM_x_at

1560023_x_at

17077312

17119702

200949_PM_x_at

200949_x_at

214003_PM_x_at

214003_x_at

216247_PM_at

216247_at

2559158

2823290

3136130

3136131

3136132

3136133

3136134

3136135

3136136

3136137

3136138

3136139

3136140

3136141

3136142

3136143

3136144

3136145

3136146

3136147

3136148

3136149

3136150

3136151

32438_at

326_i_at

327_f_at

60359_at

6224

8150872

8150877

A_21_P0000017

A_21_P0000242

A_23_P168898

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006396

GO:0006412

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0045202

GO:0070062

GO:0097371

GO:0098772

GO:1901798

GO:1990904

GO:1990948

HMNXSV003012170

HMNXSV003030093

HMNXSV003047846

Hs.8102.1.S1_3p_x_at

Hs.8102.2.A1_3p_at

Hs.8102.2.A1_3p_x_at

Hs2.133043.1.S1_3p_at

Hs2.133043.1.S1_3p_x_at

ILMN_1663681

ILMN_1701596

PH_hs_0037754

PH_hs_0039201

RNA33788|snoRNA_scaRNA_384_63

TC08001228.hg

Participates

as a component of

K63polyUb-40S ribosomal subunit [cytosol] (Homo sapiens)

Other forms of this molecule

RPS20 [cytosol]

RPS20 [nucleoplasm]

Inferred To

Ghost homologue of K63polyUb-K8-RPS20 [cytosol] (Xenopus tropicalis)

Rps20 [cytosol] (Mus musculus)

Rps20 [cytosol] (Rattus norvegicus)

rps-20 [cytosol] (Caenorhabditis elegans)

rps20 [cytosol] (Danio rerio)

rps20 [cytosol] (Dictyostelium discoideum)

rps20 [cytosol] (Schizosaccharomyces pombe)

K63polyUb-K8-RPS20 [cytosol] (Plasmodium falciparum)

RpS20 [cytosol] (Drosophila melanogaster)

LOC119865194 [cytosol] (Canis familiaris)

RPS20 [cytosol] (Bos taurus)

RPS20 [cytosol] (Gallus gallus)

RPS20 [cytosol] (Saccharomyces cerevisiae)

RPS20 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 8

Coordinate

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001139699.1, NP_001014.1

OpenTargets

ENSG00000008988

ENSEMBL

ENST00000519807, ENSP00000504154, ENSP00000427788, ENST00000676918, ENSP00000503327, ENST00000676461, ENST00000009589, ENST00000521262, ENSP00000009589, ENSP00000429374, ENST00000678683, ENST00000678039, ENSP00000504123, ENSG00000008988, ENSP00000504670

HPA

ENSG00000008988-RPS20

GeneCards

RPS20

PRO

P60866

Pharos - Targets

P60866

Orphanet

RPS20

GlyGen

P60866

PDB

8G6J, 8XSX, 5FLX, 6Z6M, 6QZP, 8QOI, 5VYC, 8ZDD, 6ZOJ, 6ZME, 8JDM, 6OLG, 6XA1, 6ZUO, 8XXM, 4V6X, 8PJ3, 8PJ4, 8PPK, 6ZXH, 6ZLW, 9G8M, 9G8O, 6ZXE, 7QP7, 7XNY, 8IFE, 5LKS, 6IP5, 6ZON, 6Z6N, 6ZVJ, 6G53, 6ZMW, 6ZMI, 9C3H, 8T4S, 8K2C, 6Y2L, 5OA3, 8JDL, 6OLE, 8Y0X, 8PJ6, 8G61, 6Y0G, 8XXL, 8PJ2, 7R4X, 8XP3, 6ZXF, 9BLN, 8PJ1, 8YOP, 4UG0, 7QP6, 6IP6, 8IFD, 8XSZ, 6ZOL, 6G51, 6Z6L, 6ZN5, 8ZDC, 6ZMO, 6OM0, 8JDK, 8G60, 6ZM7, 6OLF, 6G5H, 7K5I, 8PPL, 8PJ5, 5AJ0, 8UKB, 6YBS, 6Y57, 6OLZ, 7TQL, 6ZXG, 8XP2, 6ZVH, 6ZP4, 6OM7, 7XNX, 8XSY, 5T2C, 6ZV6, 6ZMT, 8ZDB, 6OLI, 8JDJ, 8G5Y, 6G5I, 8Y0W, 8XXN, 8GLP, 9BKD, 6FEC, 5A2Q, 7A09, 8OZ0, 8YOO, 6IP8, 6ZXD

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.715	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.688	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.623	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	5
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.527	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.482	2

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