Reactome | TCF25 [cytosol]

TCF25 [cytosol]

Stable Identifier

R-HSA-9948400

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="10"Ribosome quality control complex subunit TCF25, TCF25_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9UHJ6 SHPK

Expand all

External Reference Information

External Reference

UniProt:Q9BQ70 TCF25

Gene Names

TCF25, KIAA1049, NULP1, FKSG26

Chain

chain:1-676

Reference Genes

BioGPS Gene:22980 TCF25

COSMIC (genes):TCF25 TCF25

CTD Gene:22980 TCF25

dbSNP Gene:22980 TCF25

ENSEMBL:ENSG00000141002 TCF25

HGNC:29181 TCF25

KEGG:hsa:22980 TCF25

Monarch:22980 TCF25

NCBI Gene:22980 TCF25

OMIM:612326 TCF25

UCSC:Q9BQ70 TCF25

Reference Transcript

RefSeq:NM_014972.3 TCF25

Other Identifiers

11719688_a_at

11757470_x_at

11760608_at

16822125

17121562

213311_PM_s_at

213311_s_at

214704_PM_at

214704_at

221495_PM_s_at

221495_s_at

22980

33416_at

3674435

3674436

3674437

3674438

3674442

3674443

3674444

3674445

3674446

3674447

3674448

3674449

3674450

3674451

3674452

3674453

3674454

3674455

3674456

3674457

3674458

3674459

3674460

3674461

3674463

3674464

3674465

3674466

3674469

3674470

3674471

3674472

3674473

3674477

3674478

3674479

3674480

3674481

3674482

3674483

3674485

3674486

3674488

3674490

3674491

3674493

3674497

3674499

3674501

41267_at

41268_g_at

57842_f_at

7998033

90996_at

A_14_P100166

A_14_P108475

A_14_P113163

A_23_P49220

A_24_P306558

A_24_P306561

GE691159

GE79658

GE83805

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0061945

GO:0072344

GO:1990112

HMNXSV003012533

Hs.227835.2.A1_3p_s_at

Hs.317585.0.S1_3p_at

ILMN_1814971

PH_hs_0012665

TC16000707.hg

TC16001719.hg

g12276139_3p_a_at

Participates

as an output of

The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer (Homo sapiens)

as a component of

as an input of

LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala (Homo sapiens)

Inferred To

Nulp1 [cytosol] (Drosophila melanogaster)

RQC1 [cytosol] (Saccharomyces cerevisiae)

TCF25 [cytosol] (Bos taurus)

TCF25 [cytosol] (Caenorhabditis elegans)

TCF25 [cytosol] (Canis familiaris)

TCF25 [cytosol] (Gallus gallus)

TCF25 [cytosol] (Plasmodium falciparum)

TCF25 [cytosol] (Sus scrofa)

rqc1 [cytosol] (Schizosaccharomyces pombe)

Tcf25 [cytosol] (Mus musculus)

Tcf25 [cytosol] (Rattus norvegicus)

tcf25 [cytosol] (Danio rerio)

tcf25 [cytosol] (Dictyostelium discoideum)

tcf25 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_055787.1

ENSEMBL

ENST00000263346, ENSP00000491638, ENSP00000263346, ENST00000640279, ENSG00000141002

OpenTargets

ENSG00000141002

GeneCards

TCF25

HPA

ENSG00000141002-TCF25

PRO

Q9BQ70

Pharos - Targets

Q9BQ70

GlyGen

Q9BQ70

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.911	11
UniProt:Q96D09 GASP2			0.905	11
UniProt:P43364 MAGAB			0.742	5
UniProt:P08311 CTSG	4	CTSG [cytosol] (R-HSA-9635429) CTSG [plasma membrane] (R-HSA-538738) CTSG [extracellular region] (R-HSA-2228716) CTSG [azurophil granule lumen] (R-HSA-6799137)	0.643	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
UniProt:Q96SL4 GPX7	1	GPX7 [endoplasmic reticulum lumen] (R-HSA-3341316)	0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.527	2
UniProt:Q08830 FGL1			0.527	2
UniProt:Q9NQ55 SSF1			0.527	2
UniProt:P21953 BCKDHB	8	BCKDHB [mitochondrial matrix] (R-HSA-70015) p-S342-BCKDHB [mitochondrial matrix] (R-HSA-5693124) Q346R BCKDHB [mitochondrial matrix] (R-HSA-9865060) R183P BCKDHB [mitochondrial matrix] (R-HSA-9865041) R170H BCKDHB [mitochondrial matrix] (R-HSA-9865071) G278S BCKDHB [mitochondrial matrix] (R-HSA-9865069) N176Y BCKDHB [mitochondrial matrix] (R-HSA-9865063) H206R BCKDHB [mitochondrial matrix] (R-HSA-9865047)	0.527	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.527	2
UniProt:Q9UHJ6 SHPK	1	SHPK [cytosol] (R-HSA-8959710)	0.527	3

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