Reactome | PIM1 [cytosol]

PIM1 [cytosol]

Stable Identifier

R-HSA-9954209

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q8IZD4 DCP1B

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
      - GBP-mediated host defense (Homo sapiens)
        
        Regulation of GBP-mediated host defense (Homo sapiens)
        
        PIM1 phosphorylates GBP1 (Homo sapiens)
        
        PIM1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15657054	Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002 Jacobs, MD, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K	J Biol Chem	2005

External Reference Information

External Reference

UniProt:P11309 PIM1

Gene Names

PIM1

Chain

chain:1-313

Reference Genes

BioGPS Gene:5292 PIM1

COSMIC (genes):PIM1 PIM1

CTD Gene:5292 PIM1

dbSNP Gene:5292 PIM1

ENSEMBL:ENSG00000137193 PIM1

HGNC:8986 PIM1

KEGG:hsa:5292 PIM1

Monarch:5292 PIM1

NCBI Gene:5292 PIM1

OMIM:164960 PIM1

UCSC:P11309 PIM1

Reference Transcript

Other forms of this molecule

PIM1 [nucleoplasm]

Inferred To

LOC119881670 [cytosol] (Canis familiaris)

Pim1 [cytosol] (Rattus norvegicus)

PIM1 [cytosol] (Bos taurus)

PIM1 [cytosol] (Gallus gallus)

PIM1 [cytosol] (Sus scrofa)

pim1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001230115.1, NP_002639.1

ZINC - World Drugs

PIM1_HUMAN

Guide to Pharmacology - Targets

2158

OpenTargets

ENSG00000137193

ENSEMBL

ENST00000373509, ENSP00000362608, ENSG00000137193

ZINC - FDA approved

PIM1_HUMAN

ZINC - Substances

PIM1_HUMAN

ZINC - Biogenic

PIM1_HUMAN

ZINC target

P11309

PRO

P11309

GlyGen

P11309

PDB

3BGZ, 5DWR, 2XJ0, 3F2A, 6KZI, 5TEX, 8R0Y, 2XIZ, 5N52, 2XJ2, 5KCX, 4ENY, 5N51, 5DHJ, 5N4O, 5O13, 5MZL, 6BSK, 3VBQ, 7OOX, 5N4V, 3UIX, 6L11, 3CXW, 6YKD, 3VBW, 7Z6U, 5O11, 3CY3, 4BZO, 6L15, 3T9I, 4GW8, 4TY1, 6L14, 1YXT, 4AS0, 3R00, 5TEL, 8R1T, 3A99, 6AYD, 5DIA, 6PCW, 2O64, 4MTA, 3JXW, 4ALU, 8R27, 2J2I, 3R04, 8R10, 3MA3, 3VBV, 3UMW, 4N6Y, 4MBL, 5N4X, 2XIX, 5N50, 4K0Y, 4JX3, 6PDO, 6VRV, 4ENX, 5N5L, 5KGD, 7OOW, 3BWF, 6VRU, 3VBX, 4RC4, 2O3P, 7QFM, 1YHS, 6MT0, 3BGQ, 1XWS, 2BIL, 4RBL, 6L13, 1YXS, 1YXV, 5EOL, 8R25, 4DTK, 5VUC, 8R1K, 7VSY, 3UMX, 5TOE, 3JPV, 6PDI, 8R0H, 2XIY, 6NO9, 3C4E, 4ALW, 8R0W, 7QB2, 5VUA, 4K18, 3WE8, 4N70, 4K1B, 4MBI, 5N4Z, 3VBT, 3R01, 4A7C, 6PDN, 4RPV, 5N4N, 7XSV, 5KGK, 1YI4, 8R1W, 2BZI, 5KGI, 1YWV, 5C1Q, 4WSY, 5V82, 4RC2, 4WT6, 4IAA, 8AFR, 5TUR, 3CY2, 2BIK, 4LMU, 4ALV, 5VUB, 3JY0, 3DCV, 2O63, 7ZUN, 2BZK, 4I41, 4N6Z, 5N4R, 1XQZ, 4LL5, 2XJ1, 5KGG, 6NO8, 3QF9, 8R18, 8R1P, 2OI4, 3VC4, 4JX7, 1XR1, 5N4Y, 6PDP, 3R02, 5KGE, 5NDT, 3VBY, 4WRS, 5DGZ, 5N5M, 5N4U, 6L12, 1YI3, 4RC3, 1YXX, 4LM5, 2BZH, 5O12, 6L16, 4BZN, 6L17, 5KZI, 3BGP, 2OBJ, 1YXU, 5V80, 3JYA, 4XH6, 8R1N, 5IPJ, 5IIS, 6QXK, 7OOV, 2O65, 2C3I, 8R0Q, 2BZJ, 4XHK

ZINC - Investigational

PIM1_HUMAN

ZINC - Metabolites

PIM1_HUMAN

HPA

ENSG00000137193-PIM1

GeneCards

PIM1

Pharos - Targets

P11309

ZINC - Predictions - Purchasable

PIM1_HUMAN

HMDB Protein

HMDBP01271

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.643	4
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.633	7
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.556	3
UniProt:Q9Y2K1 ZBTB1			0.556	3
UniProt:P0C1Z6-2 TFPT			0.556	3
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P51116 FXR2			0.556	3
UniProt:Q5T203 Q5T203			0.556	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.527	3
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.527	2

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